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New drug cocktail aims to tackle tough lymphoma

NCT ID NCT04077723

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new drug called englumafusp alfa, which helps the immune system attack cancer cells. It is given together with either obinutuzumab or glofitamab to people whose B-cell non-Hodgkin lymphoma has returned or stopped responding to treatment. The trial has three parts and will check safety, side effects, and whether the combination shrinks tumors. About 498 participants are expected to take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

englumafusp alfa (a targeted protein that boosts immune cells) combined with obinutuzumab or glofitamab (antibody drugs)

What this could lead to

If successful, this could offer a new treatment option for people with hard-to-treat B-cell non-Hodgkin lymphoma that has not responded to prior therapies.

What could go wrong

This is an early-phase trial (phase I/II) with a small number of participants, so the drug may not prove effective or safe enough for wider use. Side effects from immune activation are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma lymphoma, non-Hodgkin, familial non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA, NON-HODGKIN

Contacts and locations

Locations

  • Aarhus Universitetshospital Skejby

    Aarhus N, 8200, Denmark

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asst Papa Giovanni Xxiii

    Bergamo, Lombardy, 24127, Italy

  • Auckland City Hospital, Cancer and Blood Research

    Auckland, 1023, New Zealand

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • CHRU de Lille

    Lille, 59037, France

  • CHU DE RENNES - CHU Pontchaillou

    Rennes, 35033, France

  • CHU Montpellier - Saint ELOI

    Montpellier, 34295, France

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

  • City of Hope Medical Center

    Pasadena, California, 91105, United States

  • Fudan University Shanghai Cancer Center

    Shanghai, 201315, China

  • Hospital Clinico Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Irccs Istituto Europeo Di Oncologia (IEO)

    Milan, Lombardy, 20141, Italy

  • Istituto Clinico Humanitas

    Rozzano, Lombardy, 20089, Italy

  • Istituto Nazionale Tumori Irccs Fondazione g. Pascale

    Naples, Campania, 80131, Italy

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Odense Universitetshospital

    Odense C, 5000, Denmark

  • Peter Maccallum Cancer Centre

    Melbourne, Victoria, 3000, Australia

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • Queen Elizabeth II Health Sciences Centre

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • Rigshospitalet

    København Ø, 2100, Denmark

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Shandong Cancer Hospital

    Jinan, 250117, China

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • The First Affiliated Hospital of Xiamen University

    Xiamen, 361003, China

  • The HOPE Clinical Trials Unit

    Leicester, LE1 5WW, United Kingdom

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030-4009, United States

  • UZ Gent

    Ghent, 9000, Belgium

  • University College London Hospitals NHS Foundation Trust

    London, W1T 7HA, United Kingdom

  • University of California San Francisco

    San Francisco, California, 94158, United States

  • Waikato Hospital - Cancer and Blood Research Trials Unit

    Hamilton, 3204, New Zealand

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States