New drug shows promise for rare urinary tract cancer before surgery

NCT ID NCT05868265

First seen Nov 21, 2025 · Last updated May 13, 2026 · Updated 21 times

Summary

This study tests if the drug enfortumab vedotin can shrink or eliminate high-grade urothelial carcinoma in the upper urinary tract before standard surgery. It is for 24 people who cannot or choose not to take the chemotherapy drug cisplatin. The main goal is to see if the drug can clear all cancer cells from the surgical sample.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

    RECRUITING

    Basking Ridge, New Jersey, 07920, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    RECRUITING

    Montvale, New Jersey, 07645, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)

    RECRUITING

    New York, New York, 10065, United States

    Contact Phone: •••-•••-••••

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    RECRUITING

    Middletown, New Jersey, 07748, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Nassau (Limited protocol activities)

    RECRUITING

    Uniondale, New York, 11553, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Suffolk - Commack (Limited protocol activities)

    RECRUITING

    Commack, New York, 11725, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    RECRUITING

    Harrison, New York, 10604, United States

    Contact Phone: •••-•••-••••

  • University of Rochester Medical Center (Data Collection Only)

    RECRUITING

    Rochester, New York, 14642, United States

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.