New drug shows promise against Hard-to-Treat cancers

NCT ID NCT04225117

Ongoing Disease control Sponsor: Astellas Pharma Global Development, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called enfortumab vedotin in 329 adults with advanced solid tumors that have spread. The main goal is to see if the drug shrinks tumors. Researchers also check how long the effect lasts and monitor side effects. Some participants also receive another drug, pembrolizumab.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast neoplasm Esophageal Neoplasms Head and Neck Neoplasms hormone receptor-positive breast cancer metastatic malignant neoplasm non-small cell lung carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED OR METASTATIC MALIGNANT SOLID TUMORS

Contacts and locations

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Locations

Arizona Oncology

Tucson, Arizona, 85711, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89169, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Florida Cancer Specialists

Fort Myers, Florida, 33901, United States
Florida Cancer Specialists

Tallahassee, Florida, 32308, United States
Florida Cancer Specialists

West Palm Beach, Florida, 33401, United States
Gettysburg Cancer Center

Gettysburg, Pennsylvania, 17375, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Indiana University Cancer Center

Indianapolis, Indiana, 46202, United States
Mary Crowley Research Center

Dallas, Texas, 75230, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10022, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
New York University Langone Health

New York, New York, 10016, United States
Northside Hospital

Atlanta, Georgia, 30342, United States
Northwestern University Medical Center

Chicago, Illinois, 60611, United States
Ohio State University

Columbus, Ohio, 43210, United States
Piedmont Hospital

Atlanta, Georgia, 30318, United States
Rutgers Cancer Institute

New Brunswick, New Jersey, 08901, United States
Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Site CA15003

Ottawa, Ontario, K1H 8L6, Canada
Site JP81001

Kashiwa, Chiba, Japan
Site JP81002

Koto, Tokyo, Japan
Site JP81003

Chūō, Tokyo, Japan
Site JP81004

Nagoya, Aichi-ken, Japan
Site JP81005

Chuo-ku, Osaka, Japan
Site JP81006

Nakatogari, Shizuoka, Japan
Site JP81007

Ōsaka-sayama, Osaka, Japan
Site JP81010

Okayama, Japan
Site JP81011

Kitaadachi-Gun, Saitama, Japan
University of California - San Francisco

San Francisco, California, 94158, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Kansas

Fairway, Kansas, 66205, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Minnesota Cancer Center

Minneapolis, Minnesota, 55455, United States
University of Texas

Houston, Texas, 77030, United States
Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53792, United States