New hope to stop endometrial cancer from coming back

NCT ID NCT04214067

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding an immunotherapy drug called pembrolizumab to standard radiation treatment is better at preventing cancer from returning in patients with early-stage endometrial cancer. The trial will compare radiation alone versus radiation plus pembrolizumab in 164 patients who have already had surgery. Researchers want to see if boosting the immune system helps keep the cancer away longer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Adams Cancer Center

Gettysburg, Pennsylvania, 17325, United States
AdventHealth Littleton

Littleton, Colorado, 80122, United States
AdventHealth Parker

Parker, Colorado, 80138, United States
AdventHealth Porter

Denver, Colorado, 80210, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Ascension All Saints Hospital

Racine, Wisconsin, 53405, United States
Ascension Columbia Saint Mary's Hospital - Milwaukee

Milwaukee, Wisconsin, 53211, United States
Ascension Columbia Saint Mary's Hospital Ozaukee

Mequon, Wisconsin, 53097, United States
Ascension Medical Group Southeast Wisconsin - Mayfair Road

Wauwatosa, Wisconsin, 53226, United States
Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, 53132, United States
Ascension Saint Francis Hospital

Milwaukee, Wisconsin, 53215, United States
Ascension Saint Vincent Indianapolis Hospital

Indianapolis, Indiana, 46260, United States
Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, 53045, United States
Ascension Southeast Wisconsin Hospital - Franklin

Franklin, Wisconsin, 53132, United States
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus

Milwaukee, Wisconsin, 53210, United States
Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Aultman Health Foundation

Canton, Ohio, 44710, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Baptist Health Louisville

Louisville, Kentucky, 40207, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
Ben Taub General Hospital

Houston, Texas, 77030, United States
Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
CTCA at Southeastern Regional Medical Center

Newnan, Georgia, 30265, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Cancer Center-Metro Medical Center Bayamon

Bayamón, 00959-5060, Puerto Rico
Carilion Roanoke Memorial Hospital

Roanoke, Virginia, 24033, United States
Carlisle Regional Cancer Center

Carlisle, Pennsylvania, 17015, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Centro Comprensivo de Cancer de UPR

San Juan, 00927, Puerto Rico
Chester County Hospital

West Chester, Pennsylvania, 19380, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States
Community Cancer Institute

Clovis, California, 93611, United States
Community Medical Center

Missoula, Montana, 59804, United States
Cone Health Cancer Center

Greensboro, North Carolina, 27403, United States
Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States
Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States
Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124, United States
Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Danbury Hospital

Danbury, Connecticut, 06810, United States
Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Doctors Cancer Center

Manatí, 00674, Puerto Rico
Dublin Methodist Hospital

Dublin, Ohio, 43016, United States
Duke Cancer Center Raleigh

Raleigh, North Carolina, 27609, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Duke Women's Cancer Care Raleigh

Raleigh, North Carolina, 27607, United States
East Jefferson General Hospital

Metairie, Louisiana, 70006, United States
Ephrata Cancer Center

Ephrata, Pennsylvania, 17522, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Farmington Health Center

Farmington, Utah, 84025, United States
Geauga Hospital

Chardon, Ohio, 44024, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
GenesisCare USA - FGO

Fort Myers, Florida, 33905, United States
Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, 96817, United States
Highland Hospital

Rochester, New York, 14620, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Houston Methodist Sugar Land Hospital

Sugar Land, Texas, 77479, United States
Houston Methodist The Woodlands Hospital

The Woodlands, Texas, 77385, United States
Houston Methodist West Hospital

Houston, Texas, 77094, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Jersey Shore Medical Center

Neptune City, New Jersey, 07753, United States
John Muir Medical Center-Concord

Concord, California, 94520, United States
John Muir Medical Center-Walnut Creek

Walnut Creek, California, 94598, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Lancaster General Ann B Barshinger Cancer Institute

Lancaster, Pennsylvania, 17601, United States
Lancaster General Hospital

Lancaster, Pennsylvania, 17602, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States
Legacy Meridian Park Hospital

Tualatin, Oregon, 97062, United States
Legacy Mount Hood Medical Center

Gresham, Oregon, 97030, United States
Legacy Salmon Creek Hospital

Vancouver, Washington, 98686, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Long Island Jewish Medical Center

New Hyde Park, New York, 11040, United States
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
Louisiana State University Health Science Center

New Orleans, Louisiana, 70112, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
MD Anderson League City

League City, Texas, 77573, United States
MD Anderson West Houston

Houston, Texas, 77079, United States
MD Anderson in Sugar Land

Sugar Land, Texas, 77478, United States
MD Anderson in The Woodlands

Conroe, Texas, 77384, United States
MaineHealth Cancer Care and IV Therapy - Sanford

Sanford, Maine, 04073, United States
MaineHealth Coastal Cancer Treatment Center

Bath, Maine, 04530, United States
MaineHealth Maine Medical Center - Biddeford

Biddeford, Maine, 04005, United States
MaineHealth Maine Medical Center - Portland

Portland, Maine, 04102, United States
MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mary Greeley Medical Center

Ames, Iowa, 50010, United States
McFarland Clinic - Ames

Ames, Iowa, 50010, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Health University Medical Center

Savannah, Georgia, 31404, United States
Memorial Hospital North

Colorado Springs, Colorado, 80920, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Methodist Willowbrook Hospital

Houston, Texas, 77070, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Miami Valley Hospital South

Centerville, Ohio, 45459, United States
Midwestern Regional Medical Center

Zion, Illinois, 60099, United States
Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Mount Carmel East Hospital

Columbus, Ohio, 43213, United States
Mount Carmel Grove City Hospital

Grove City, Ohio, 43123, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
Mount Carmel New Albany Surgical Hospital

New Albany, Ohio, 43054, United States
Mount Sinai Chelsea

New York, New York, 10011, United States
Mount Sinai Hospital

New York, New York, 10029, United States
Mount Sinai West

New York, New York, 10019, United States
NYP/Weill Cornell Medical Center

New York, New York, 10065, United States
NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

Omaha, Nebraska, 68114, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215, United States
NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States
NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026, United States
NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035, United States
Northside Hospital

Atlanta, Georgia, 30342, United States
Northside Hospital-Forsyth

Cumming, Georgia, 30041, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States
Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States
Northwestern University

Chicago, Illinois, 60611, United States
Norwalk Hospital

Norwalk, Connecticut, 06856, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Oncology Associates PC

Omaha, Nebraska, 68114, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States
Parkland Memorial Hospital

Dallas, Texas, 75235, United States
Pennsylvania Hospital

Philadelphia, Pennsylvania, 19107, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States
Regional Cancer Center-Lee Memorial Health System

Fort Myers, Florida, 33905, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Elizabeth Healthcare Edgewood

Edgewood, Kentucky, 41017, United States
Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States
Saint Francis Hospital

Greenville, South Carolina, 29601, United States
Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
San Juan City Hospital

San Juan, 00936, Puerto Rico
San Juan Community Oncology Group

San Juan, 00917, Puerto Rico
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Sechler Family Cancer Center

Lebanon, Pennsylvania, 17042, United States
Sinai Hospital of Baltimore

Baltimore, Maryland, 21215, United States
Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States
Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, 06437, United States
Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385, United States
Smilow Cancer Hospital Care Center - Westerly

Westerly, Rhode Island, 02891, United States
Smilow Cancer Hospital Care Center at Glastonbury

Glastonbury, Connecticut, 06033, United States
Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, 06830, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Smilow Cancer Hospital Care Center-Fairfield

Fairfield, Connecticut, 06824, United States
Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital-Derby Care Center

Derby, Connecticut, 06418, United States
Smilow Cancer Hospital-Orange Care Center

Orange, Connecticut, 06477, United States
Smilow Cancer Hospital-Torrington Care Center

Torrington, Connecticut, 06790, United States
Smilow Cancer Hospital-Waterbury Care Center

Waterbury, Connecticut, 06708, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
The New York Hospital Medical Center of Queens

Flushing, New York, 11355, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095, United States
UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States
UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060, United States
UH Seidman Cancer Center at Saint John Medical Center

Westlake, Ohio, 44145, United States
UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122, United States
UHHS-Westlake Medical Center

Westlake, Ohio, 44145, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601, United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, 17050, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States
UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Hospitals Sharon Health Center

Wadsworth, Ohio, 44281, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
University Oncology Associates

Clovis, California, 93611, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Chicago Medicine-Orland Park

Orland Park, Illinois, 60462, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Utah Sugarhouse Health Center

Salt Lake City, Utah, 84106, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Virtua Samson Cancer Center

Moorestown, New Jersey, 08057, United States
Virtua Voorhees

Voorhees Township, New Jersey, 08043, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
WellSpan Health-York Cancer Center

York, Pennsylvania, 17403, United States
WellSpan Health-York Hospital

York, Pennsylvania, 17403, United States
Wellstar Kennestone Hospital

Marietta, Georgia, 30060, United States
West Virginia University Charleston Division

Charleston, West Virginia, 25304, United States
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States
Women and Infants Hospital

Providence, Rhode Island, 02905, United States
Women's Cancer Care Associates LLC

Albany, New York, 12208, United States
Women's Cancer Center of Nevada

Las Vegas, Nevada, 89106, United States
Yale University

New Haven, Connecticut, 06520, United States
Yale-New Haven Hospital North Haven Medical Center

North Haven, Connecticut, 06473, United States

Conditions

Explore the condition pages connected to this study.

ENDOMETRIAL ENDOMETRIOID ADENOCARCINOMA STAGE I UTERINE CORPUS CARCINOMA OR CARCINOSARCOMA AJCC V8 STAGE II UTERINE CORPUS CARCINOMA OR CARCINOSARCOMA AJCC V8