New drug cocktail shows promise in liver cancer battle

NCT ID NCT05301842

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Apr 15, 2026 · Last updated Apr 26, 2026 · Updated 3 times

Summary

This study tests whether adding two immunotherapy drugs (durvalumab and tremelimumab) and a targeted therapy (lenvatinib) to a standard liver cancer procedure called TACE can help people with liver cancer that has not spread. About 760 participants will be randomly assigned to receive TACE alone or TACE plus the drug combination. The main goal is to see if the combination delays cancer growth or improves survival.

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Contacts and locations

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Locations

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Birmingham, Alabama, 35233, United States
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Mobile, Alabama, 36607, United States
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Yuma, Arizona, 85364, United States
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Glendale, California, 91204, United States
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Atlanta, Georgia, 30318, United States
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Baltimore, Maryland, 21201, United States
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Santa Fe, New Mexico, 87505, United States
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Commack, New York, 11725, United States
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New York, New York, 10029, United States
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Memphis, Tennessee, 38104, United States
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Dallas, Texas, 75235, United States
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Houston, Texas, 77030, United States
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Brussels, 1070, Belgium
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Ghent, 9000, Belgium
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Barretos, 14784-400, Brazil
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Brasília, 71681-603, Brazil
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Niterói, 24020-096, Brazil
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Porto Alegre, 91350-200, Brazil
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Rio de Janeiro, 20231-050, Brazil
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Santa Maria, 97015-450, Brazil
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Santo André, 09060-650, Brazil
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São Paulo, 04014-002, Brazil
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Vitória, 29043-272, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Kingston, Ontario, K7L 5P9, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H2X 3E4, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Beijing, 100021, China
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Beijing, 100069, China
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Beijing, 100142, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Fuzhou, 350001, China
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Fuzhou, 350011, China
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Guangzhou, 510060, China
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Guangzhou, 510515, China
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Haikou, 570311, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230001, China
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Lanzhou, 730030, China
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Lishui, 323000, China
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Nanchang, 330006, China
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Nanjing, 210002, China
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Nantong, 226361, China
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Neijiang, 641000, China
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Shanghai, 200032, China
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Suzhou, 215004, China
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Tianjin, 300170, China
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Wenzhou, 325000, China
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Wuhan, 430010, China
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Wuhan, 430022, China
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Xi'an, 710000, China
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Zhengzhou, 450008, China
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Zhuhai, 519000, China
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Al Mansurah, 7650001, Egypt
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Cairo, 11451, Egypt
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Shebeen El Kom, 32511, Egypt
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Angers, 49933, France
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Clichy, 92110, France
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Créteil, 94010, France
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Montpellier, 34295, France
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Nantes, 44093, France
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Nice, 06200, France
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Paris, 75013, France
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Strasbourg, 67091, France
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Toulouse, 31059, France
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Vandœuvre-lès-Nancy, 54511, France
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Bonn, 53127, Germany
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Chemnitz, 09116, Germany
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Dresden, 01307, Germany
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Düsseldorf, 40225, Germany
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Frankfurt, 60596, Germany
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Göttingen, 37075, Germany
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Hamburg, 22291, Germany
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Hanover, 30625, Germany
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Heidelberg, 69120, Germany
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Kiel, 24105, Germany
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Leipzig, 04103, Germany
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Magdeburg, 39120, Germany
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Ulm, 89081, Germany
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Ahmedabad, 380054, India
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Ahmedabad, 380060, India
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Bangalore, 560027, India
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Delhi, 110029, India
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Hyderabad, 500032, India
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Jaipur, 302022, India
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Kolkata, 700099, India
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Mumbai, 400012, India
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New Delhi, 110 085, India
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New Delhi, 110005, India
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Arezzo, 52100, Italy
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Florence, 50134, Italy
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Milan, 20132, Italy
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Milan, 20133, Italy
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Roma, 00128, Italy
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Rozzano, 20089, Italy
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Tricase, 73039, Italy
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Chūōku, 104-0045, Japan
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Fukuoka, 810-8563, Japan
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Hiroshima, 734-8551, Japan
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Kashihara-shi, 634-8522, Japan
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Kashiwa, 277-8577, Japan
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Kumamoto, 860-8556, Japan
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Mitaka-shi, 181-8611, Japan
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Morioka, 028-3695, Japan
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Musashino-shi, 180-8610, Japan
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Okayama, 700-8558, Japan
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Osaka, 543-8555, Japan
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Osaka, 545-8586, Japan
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Osakasayama-shi, 589-8511, Japan
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Sapporo, 006-8555, Japan
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Sendai, 981-0914, Japan
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Sunto-gun, 411-8777, Japan
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Tokushima, 770-8503, Japan
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Tsu, 514-8507, Japan
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Yokohama, 241-8515, Japan
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Bandar Puncak Alam, 42300, Malaysia
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George Town, 10450, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuala Selangor, 62250, Malaysia
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Kuching, 93586, Malaysia
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Guadalajara, Jalisco, 44280, Mexico
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México, 1400, Mexico
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San Luis Potosí City, 78209, Mexico
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Tuxtla Gutiérrez, 29090, Mexico
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Davao City, 8000, Philippines
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Makati, 1229, Philippines
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Manila, 1003, Philippines
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Pasig, 1600, Philippines
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Quezon City, 1112, Philippines
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Lisbon, 1649-035, Portugal
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Vila Real, 5000-508, Portugal
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Hato Rey Central, 00917, Puerto Rico
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San Juan, 00927, Puerto Rico
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Jeddah, 22384, Saudi Arabia
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Riyadh, 12713, Saudi Arabia
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Busan, 49241, South Korea
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Daegu, 42601, South Korea
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Goyang-si, 10408, South Korea
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Junggu, 41944, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Barcelona, 08036, Spain
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Córdoba, 14004, Spain
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Donostia / San Sebastian, 20014, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 100, Taiwan
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Taipei, TAIWAN, Taiwan
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Taoyuan District, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10300, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Hanoi, 100000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam

Conditions

Explore the condition pages connected to this study.

HEPATOCELLULAR CARCINOMA