New pill shows promise for advanced breast cancer in early trial
NCT ID NCT05596409
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests the drug elacestrant in 61 people with estrogen receptor-positive, HER2-negative metastatic breast cancer who have not previously used CDK4/6 inhibitors. Participants take a daily pill for about 6 months. The study aims to see if the drug can delay cancer progression and shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Elacestrant (a hormone therapy pill taken once daily)
What this could lead to
If successful, this could provide a new oral treatment option for people with a common type of advanced breast cancer who haven't tried CDK4/6 inhibitors yet.
What could go wrong
This is a small, early-phase (Phase 2) study with only 61 participants, so results may not apply to everyone. The drug may not improve survival or could cause side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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COMPLEX ONCOLOGICAL CENTER - Shumen
Shumen, 9700, Bulgaria
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Centro De Pesquisa Clinica DO Hospital Sirio-Libanes - UNIDADE Brasilia
Brasília, 70200-730, Brazil
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Centro de Estudos e Pesquisas de Hematologia e Oncologia- CEPHO
Santo André, São Paulo, 09060-650, Brazil
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Centro de Pesquisas Clinicas em Oncologia (Center for Clinical Research in Oncology (CPCO)) - Hospital Evangélico de Cachoeiro de Itapemirim
Cachoeiro de Itapemirim, Espírito Santo, 29308-014, Brazil
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Centro de Pesquisas Oncologicas
Florianópolis, Santa Catarina, 88034-000, Brazil
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Clinica de Pesquisas e Centro de Estudos Em Oncologia Ginecologica e Mamaria Ltda
São Paulo, 01317-001, Brazil
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Complex Oncology Center
Plovdiv, 4000, Bulgaria
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Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89128, United States
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Fucam, Ac.
Mexico City, 4980, Mexico
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Highlands Oncology Group, PA
Springdale, Arkansas, 72762, United States
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Hospital São Lucas PUCRS - Centro de Pesquisa em Oncologia (CPO)
Porto Alegre, Rio Granda Do Sul, 70200-730, Brazil
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Hospital de Amor de Barretos
Barretos, São Paulo, 14784-400, Brazil
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Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Granda Do Sul, 90035, Brazil
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I CAN Oncology Center, Centro Medico AVE
Monterrey, Nuevo León, 64710, Mexico
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Innova Medical Center
Tbilisi, 179, Georgia
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Institute of Clinical Oncology
Tbilisi, Georgia
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Institutul Oncologic "Prof. Dr. Ion Chiricuta" Cluj Napoca
Cluj-Napoca, Cluj, 400150, Romania
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LTD Simon Khechinashvili University Clinic
Tbilisi, 179, Georgia
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Northwestern University, Northwestern Feinberg School of Medicine Prentice Women's Hospital
Chicago, Illinois, 60611, United States
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Torre Medica Hospital Dalinde
Mexico City, 06760, Mexico
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UT Health San Antonio Mays Cancer Center
San Antonio, Texas, 78229, United States
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Unidad Médica Onco-Hematológica
Puebla City, 4515, Mexico