New hope for advanced melanoma: experimental combo enters late-stage trial

NCT ID NCT06697301

Recruiting now Disease control Sponsor: Eikon Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding an experimental drug (EIK1001) to standard immunotherapy (pembrolizumab) helps people with advanced melanoma live longer without their cancer growing. About 740 adults with stage 3 or 4 melanoma that cannot be removed by surgery will receive either the combination or a placebo plus pembrolizumab. The main goals are to see if the new combo improves survival and slows cancer progression.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma melanoma metastatic melanoma Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MELANOMA

Contacts and locations

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Locations

A Paré
RECRUITING

Boulogne, Boulogne, 92104, France
Aalborg University Hospital
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Aalborg, Nord Jutland, 9000, Denmark
Aarhus Universitetshospital
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Aarhus, Central Jutland, 8200, Denmark
Abraham Oncology
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Richards Bay, KwaZulu-Natal, 3900, South Africa
Algemeen Ziekenhuis Groeninge - Campus Kennedylaan
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Kortrijk, West-Vlaanderen, 8500, Belgium
Auckland City Hospital
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Auckland, New Zealand, 1023, New Zealand
Belfast City Hospital, Belfast Health and Social Care Trust
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Belfast, Belfast, BT9 7AB, United Kingdom
Bioresearch Partner
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Hialeah, Florida, 33013, United States
CHU Lille
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Polonovski, Lille Cedex, 59037, France
CHU Rouen
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Rouen, Rouen, 76031, France
Cancer Care Wollongong
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Wollongong, New South Wales, 2500, Australia
Cancercare Port Elizabeth - Langenhoven Drive Oncology Centre
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Port Elizabeth, Eastern Cape, 6045, South Africa
Cape Town Oncology Trials
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Cape Town, Western Cape, 7570, South Africa
Centre Hospitalier Lyon-Sud
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Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
Centre Hospitalier Universitaire (CHU) Nice
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Nice, PACA, 06200, France
Centre Hospitalier Universitaire Grenoble Alpes
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La Tronche, Isère, 38700, France
Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne
RECRUITING

Yvoir, Namur, B-5530, Belgium
Charite Department of Dermatology, Venereology and Allergology
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Berlin, State of Berlin, 10115, Germany
Christchurch Public Hospital
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Christchurch, Christchurch, 8011, New Zealand
Clinica Oncologia Delle Marche
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Ancona, The Marches, 60126, Italy
Cliniques Universitaires Saint-Luc
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Brussels, Brussels Capital, 1200, Belgium
Curo Oncology
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Pretoria, Pretoria, 0084, South Africa

Contact Email: •••••@•••••
Drammen Hospital
RECRUITING

Drammen, Oslofjord, 3004, Norway
Eastern Health
RECRUITING

Box Hill, Victoria, 3128, Australia
Elbe Kliniken Stade-Buxtehude
RECRUITING

Buxtehude, Lower Saxony, 21614, Germany
Ella Lemelbaum Institute for Immuno-Oncology and Melanoma
RECRUITING

Ramat Gan, Ramat Gan, 5262100, Israel
Fachklinik Hornheide
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Münster, 48157, Germany
Gabrail Cancer Center Research LLC
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Canton, Ohio, 44718, United States
Genesis Cancer and Blood Institute
RECRUITING

Hot Springs, Arkansas, 71913, United States
GenesisCare Madrid - Hospital San Francisco de Asís
RECRUITING

Madrid, Madrid, 28002, Spain
Guy's and St Thomas' NHS Foundation Trust
RECRUITING

London, England, SE1 9RT, United Kingdom
Gävle Sjukhus
RECRUITING

Gävle, Gävleborg County, 801 88, Sweden
H. Germans Trias I Pujol (ICO-Badalona)
RECRUITING

Badalona, Badalona, 08916, Spain
HM CIOCC
RECRUITING

Madrid, Madrid, 28050, Spain
Helios Clinical Research
RECRUITING

Los Angeles, California, 90015, United States
Helsinki University Hospital
RECRUITING

Helsinki, Uusimaa, 00029, Finland
Hospital 12 de Octubre
RECRUITING

Usera, Madrid, 28031, Spain
Hospital General Universitario Gregorio Marañón
RECRUITING

Madrid, Madrid, 28007, Spain
Hospital Regional Universitario
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Málaga, Malaga, 29011, Spain

Contact Email: •••••@•••••
Hospital Saint Andre
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Bordeaux, 33075, France
Hospital Universitari Dexeus
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Barcelona, Barcelona, 08028, Spain
Hospital Universitario Lucus Augusti
RECRUITING

Lugo, Galicia, 27003, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, Málaga, 29010, Spain
Hospital da Luz Lisboa
RECRUITING

Lisbon, Lisbon District, 1500-650, Portugal
Humanitas Gavazzeni Bergamo
RECRUITING

Bergamo, Province of Bergamo, 24125, Italy
Hôpital Bichat AP-HP Université Paris Cité
RECRUITING

Paris, Paris, 75018, France
Hôpital La Timone
RECRUITING

Marseille, Marseille, 13385, France
ICO Saint Herblain
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Saint-Herblain, Pays de la Loire Region, 44800, France
INCLIVA Instituto de Investigación Sanitaria
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Valencia, Valencia, 46010, Spain
IPO Lisboa
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Lisbon, Lisbon District, 1099-023, Portugal
IRCCS Ospedale San Raffaele
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Milan, Milano, 20132, Italy
IVO - Fundacion Instituto Valenciano de Oncologia
RECRUITING

Valencia, Valencia, 46009, Spain
Icon Cancer Centre Chermside
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Chermside, Queensland, 4032, Australia
Institut Català d'Oncologia Girona (ICO Girona)
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Girona, Girona, 17007, Spain
Ironwood Cancer & Research Centers
RECRUITING

Chandler, Arizona, 85224, United States
Johannes Wesling Klinikum Minden
RECRUITING

Minden, North Rhine-Westphalia, 32429, Germany
Kantonsspital Graubünden
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Chur, Chur, 7000, Switzerland
Karolinska University Hospital
RECRUITING

Stockholm, Södermanland County, 17176, Sweden
Klinik für Dermatologie, Venerologie und Allergologie
RECRUITING

Würzburg, Bavaria, 97080, Germany
Kyungpook National University Chilgok Hospital
RECRUITING

Buk-Gu, Daegu, 41404, South Korea
Maria Sklodowska-Curie National Cancer Research Institute
RECRUITING

Warsaw, Warsaw, 02-781, Poland
Masaryk Memorial Cancer Institute
RECRUITING

Brno, Brno, 65653, Czechia
Mazowiecki Szpital Wojewódzki, Siedlckie Centrum Onkologii
RECRUITING

Siedlce, Siedlce, 08-110, Poland
MidAmerica Cancer Care
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Kansas City, Missouri, 64132, United States
Military Medical Academy- Department of Oncology
RECRUITING

Belgrade, Belgrade, 11000, Serbia
National Institute of Oncology
RECRUITING

Budapest, Budapest, 1122, Hungary
Nordland Hospital Trust
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Bodø, Bodø, N-8005, Norway
Oslo University Hospital - The Norwegian Radium Hospital
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Oslo, Oslo, 0310, Norway
Oulu University Hospital
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Oulu, Oulu, 90230, Finland
Peninsula and South Eastern Haematology and Oncology Group
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Frankston, Victoria, 3199, Australia
Prezychodnia Lekarska KOMED Roman Karaszewski
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Konin, Konin, 62-500, Poland
Providence Medical Foundation
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Santa Rosa, California, 95403, United States
Rabin Medical Center
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Petah Tikva, Petach Tikva, 4941492, Israel
San Pedro de Alcántara Hospital
RECRUITING

Cáceres, Cáceres, 10003, Spain
Sarah Cannon Research Institute London
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London, England, W1G6AD, United Kingdom
Seoul National University Hospital
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Jongno-gu, Seoul, 03080, South Korea
Soroka medical center
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Beersheba, Be'er Sheva, 8410101, Israel
Southern Adelaide Local Health Network Incorporated Flinders Medical Centre
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Bedford Park, South Australia, 5042, Australia
Sunnybrook Research Ins<tute
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Toronto, Ontario, M4N 3M5, Canada
TASK Eden
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George Central, Western Cape, 6530, South Africa
Tampere University Hospital
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Tampere, Pirkanmaa, 33521, Finland
Tel Aviv Medical Center
RECRUITING

Tel Aviv, Tel Aviv, 6423906, Israel
The Center for Cancer and Blood Disorders
RECRUITING

Bethesda, Maryland, 20817, United States
The Medical Oncology Centre of Rosebank
RECRUITING

Saxonwold, Gauteng, 2196, South Africa
UCHealth Memorial Hospital Central
RECRUITING

Colorado Springs, Colorado, 80909, United States
UOC Immunoterapia Oncologica
RECRUITING

Siena, Tuscany, 53100, Italy
Universitaetsklinikum Tuebingen (UKT)
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitair Ziekenhuis Antwerpen
RECRUITING

Edegem, Antwerpen, 2650, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
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Leuven, Vlaams Brabant, 3000, Belgium
Universitat Leipzig
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Saxony, Leipzig, 04103, Germany
University Hospital Hradec Kralove
RECRUITING

Sokolov, Hradce Kralove, 50009, Czechia
University Hospital Southampton
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Southampton, Hampshire, SO32 2DA, United Kingdom
University Hospital of Jerez
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Jerez de La Frontera (Cádiz), Jerez de La Frontera (Cádiz), 11407, Spain
University of Mainz Medical Center
RECRUITING

Mainz, RLP, 55131, Germany
University of Pittsburgh Medical Center(UPMC)-Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Pretoria, Steve Biko Academic Hospital
RECRUITING

Pretoria, Gauteng, 0002, South Africa
University of Pécs
RECRUITING

Pécs, 7632, Hungary
Universitätsklinik Hamburg Eppendorf
RECRUITING

Martinsried, Free and Hanseatic City of Hamburg, 20246, Germany
Universitätsklinikum Graz
RECRUITING

Graz, Styria, 8036, Austria
Universitätsklinikum Schleswig-Holstein - Campus Kiel
RECRUITING

Kiel, Schleswig-Holstein, 24105, Germany
Universitätsklinikum Schleswig-Holstein - Campus Lübeck
RECRUITING

Lübeck, Schleswig-Holstein, 23538, Germany
Universitätsmedizin Mannheim
RECRUITING

Mannheim, Baden-Wurttemberg, 68167, Germany
Universitätsspital Zürich
RECRUITING

Zurich, Canton of Zurich, 8091, Switzerland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, Gdańsk, 80-952, Poland
Vall d' Hebron Institute of Oncology
RECRUITING

Barcelona, Barcelona, 08035, Spain
Vitaz Primary Location
RECRUITING

Sint-Niklaas, 9100, Belgium
Washington University School of Medicine in St. Louis
RECRUITING

St Louis, Missouri, 63108, United States

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