Can a Heart-Lung machine rescue failing lungs?
NCT ID NCT07800325
First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time
Summary
This trial tests whether ECMO, a machine that temporarily takes over heart and lung function, can safely help adults with respiratory failure who are not improving with standard care. Researchers will enroll 30 patients with high carbon dioxide levels and low blood pH, including those who struggle to come off a ventilator. The main goal is to see if ECMO improves survival, while also tracking safety and side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ECMO (extracorporeal membrane oxygenation), a machine that takes over heart and lung function to give the lungs time to recover
- What this could lead to
- If ECMO proves safe and effective, it could offer a life-saving option for people with severe respiratory failure who do not improve with standard ventilator support.
- What could go wrong
- This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. ECMO carries risks like bleeding, infection, and complications from the machine itself.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18, male or female; * Patients with respiratory failure and high Paco2, PH \< 7.35； * Researchers believe that this product is beneficial for patients undergoing treatment, such as patients with invasive ventilator weaning difficulty, large airway obstruction, etc； * Patients or guardians provided written informed consent voluntarily. Exclusion Criteria: * Oxygenation index \<80mmHg; * Intracranial hemorrhage or severe irreversible brain injury; * Thrombocytopenia; * Patients with malignant tumors (expected survival time \<1 year); * patients unable to receive systemic anticoagulation; * Obesity: BMI\>40kg/m2; * Those with a history of mental illness who were unable to cooperate in completing the trial; * During pregnancy and lactation; * Patients with allergic or severe allergic constitution to the test equipment; * Participated in other interventional device clinical trials within 3 months before this trial * Those who were deemed unsuitable to participate in the trial by the investigators.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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China-Japan Friendship Hospital
Beijing, Beijing Municipality, 102300, China
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