First human trial launches for targeted radiation therapy against Hard-to-Treat neuroendocrine tumors
NCT ID NCT06148636
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests a new radioactive drug, [212Pb] VMT-α-NET, in 24 adults with advanced neuroendocrine tumors that have not responded to other treatments. The main goal is to find a safe dose for future studies, not to treat the disease. Participants receive up to two infusions of the drug along with amino acids to protect the kidneys.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- [212Pb] VMT-α-NET (a radioactive drug)
- What this could lead to
- If successful, this could help determine a safe dose for future trials that might control tumor growth in patients with neuroendocrine tumors.
- What could go wrong
- This is an early, first-in-human safety study with only 24 participants. It is not designed to provide therapeutic benefit, and the drug may cause kidney damage or other side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Holden Comprehensive Cancer Center at the University of Iowa
Iowa City, Iowa, 52242, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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