Early intervention trial for lung blood vessel disease halted
NCT ID NCT05339087
Summary
This study aimed to see if a drug called riociguat could help control early-stage pulmonary vascular disease, a condition that can lead to high blood pressure in the lungs. It involved 35 adults with connective tissue diseases like systemic sclerosis who showed early signs of the lung condition but were not yet on specific treatment. Participants were randomly assigned to receive either the study drug or a placebo for 24 weeks to measure effects on blood vessel resistance in the lungs and exercise capacity. The trial was terminated early.
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Contacts and locations
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Locations
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Carl Gustav Carus University Hospital at the TU Dresden, Medical Department I, Center for PH
Dresden, Germany
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Centre de référence des Maladies Auto-Immunes Systémiques rares du Nord et Nord-Ouest (CeRAINO) Service de Médecine Interne et Immunologie Clinique Hôpital Claude Huriez, CHU
Lille, 59037, France
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Centre for Pulmonary Hypertension at the Thoraxklinik Heidelberg, Heidelberg University Hospital Heidelberg
Heidelberg, 69126, Germany
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LKH-Univ. Klinikum Graz Universitätsklinik für Innere Medizin Klinische Abteilung für Pulmonologie
Graz, 8036, Austria
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Ordensklinikum Linz GmbH Elisabethinen
Linz, 4020, Austria
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Royal Free London NHS Foundation Trust
London, United Kingdom
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Università Degli Studi Di Napoli Federico II Scuola Di Medicina E Chirurgia
Naples, 80131, Italy
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Universitätsspital Zürich Pulmonale Hypertonie, Klinik für Pneumologie
Zurich, 8091, Switzerland
Conditions
Explore the condition pages connected to this study.