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Experimental drug aims to slow lung scarring in IPF

NCT ID NCT05389215

Ongoing Disease control Sponsor: Daewoong Pharmaceutical Co. LTD. Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether an experimental drug called DWN12088 can safely slow the decline in lung function for people with idiopathic pulmonary fibrosis (IPF), a progressive lung-scarring disease. About 102 adults aged 40 and older with stable IPF will be randomly assigned to receive either DWN12088 or a placebo, and neither they nor their doctors will know which they receive. The study measures changes in breathing tests, lung scans, and exercise capacity over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
an experimental drug called DWN12088
What this could lead to
If successful, DWN12088 could offer a new treatment option to slow lung function decline in people with idiopathic pulmonary fibrosis.
What could go wrong
This is a mid-stage trial with only 102 participants, so results may not confirm benefit. The drug could also cause side effects not yet seen in earlier studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS

Contacts and locations

Locations

  • Ajou University Hospital

    Hwaseong-si, Gyeonggido, 16499, South Korea

  • Asan Medical Center

    Seoul, Seoul, 05505, South Korea

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Baylor Scott & White Research Institute

    Dallas, Texas, 75204, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Dignity Health Norton Thoracic Institute

    Phoenix, Arizona, 85013, United States

  • Duke University Medical Center

    Durham, North Carolina, 27705, United States

  • Inje University Busan Paik Hospital

    Busan, Busan, 47392, South Korea

  • Legacy Research Institute

    Portland, Oregon, 97232, United States

  • Lowcountry Lung and Critical Care

    Charleston, South Carolina, 29406, United States

  • Loyola University Medical Center (LUMC)

    Maywood, Illinois, 60153, United States

  • Myongji Hospital

    Goyang-si, Gyeonggi-do, 10475, South Korea

  • Penn State Milton S. Hershey Medical Center

    Hershey, Pennsylvania, 17033, United States

  • Pulmonary Associates, PA

    Mesa, Arizona, 85206-1346, United States

  • Pulmonix Research, LLC

    Greensboro, North Carolina, 27403, United States

  • Samsung Medical Center

    Seoul, Seoul, 06351, South Korea

  • Seoul National University Hospital

    Seoul, Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul, 03722, South Korea

  • Soon Chun Hyang University Hospital Bucheon

    Bucheon-si, Gyeonggido, 14584, South Korea

  • The Catholic University of Korea, Bucheon St. Mary's Hospital

    Bucheon-si, Gyeonggi-do, 14647, South Korea

  • The Lung Research Center, LLC

    Chesterfield, Missouri, 63017, United States

  • The U.S. Department of Veterans Affairs

    Charleston, South Carolina, 29401, United States

  • The University of California San Francisco

    San Francisco, California, 94143, United States

  • The University of Texas Health San Antonio Medical Arts & Research Center

    San Antonio, Texas, 78229-3901, United States

  • The University of Texas Southwestern Medical Center

    Dallas, Texas, 75390-9020, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • Ulsan University Hospital

    Ulsan, Ulsan, 44033, South Korea

  • University of Kansas Medical Center Research Institute, Inc

    Kansas City, Kansas, 66160, United States

  • University of Michigan Health System

    Michigan Center, Michigan, 48109, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

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