Major global trial aims to extend lives in Tough-to-Treat esophageal cancer

NCT ID NCT04550260

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether adding the immunotherapy drug durvalumab to standard chemotherapy and radiation helps people with advanced esophageal cancer that cannot be surgically removed. About 640 patients worldwide will receive either the new combination or standard treatment plus a placebo to see if the new approach keeps the cancer from growing longer and helps patients live longer. The main goal is to see if the drug combination is more effective, especially for patients whose tumors have a specific marker (PD-L1 High).

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Contacts and locations

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Locations

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Atlanta, Georgia, 30308, United States
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Louisville, Kentucky, 40217, United States
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Dallas, Texas, 75390, United States
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Fairfax, Virginia, 22031, United States
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Morgantown, West Virginia, 26506, United States
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Brussels, 1090, Belgium
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Charleroi, 6060, Belgium
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Liège, 4000, Belgium
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Namur, 5000, Belgium
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Barretos, 14784-400, Brazil
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Fortaleza, 60430-230, Brazil
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Porto Alegre, 90050-170, Brazil
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Porto Alegre, 91350-200, Brazil
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Rio de Janeiro, 20231-050, Brazil
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São José do Rio Preto, 15090-000, Brazil
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Vitória, 29043-260, Brazil
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Barrie, Ontario, L4M 6M2, Canada
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Greater Sudbury, Ontario, P3E 5J1, Canada
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Anyang, 455000, China
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Beijing, 100021, China
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Beijing, 100036, China
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Bengbu, 233004, China
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Changsha, 410013, China
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Changzhi, 46000, China
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Chengdu, 610042, China
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Chongqing, 400030, China
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Fuzhou, 350001, China
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Fuzhou, 350014, China
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Guangzhou, 510000, China
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Guangzhou, 510060, China
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Hangzhou, China
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Hefei, 230031, China
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Huai'an, 223300, China
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Jieyang, 522000, China
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Jinan, 250117, China
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Kunming, 650118, China
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Liangyugang, 222002, China
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Nantong, 226361, China
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Qingdao, 266042, China
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Quanzhou, 362000, China
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Shenzhen, 518116, China
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Tianjin, 300060, China
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Xi'an, 710061, China
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Xuzhou, 221000, China
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Yangzhou, 225001, China
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Zhengzhou, 450008, China
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Zhenjiang, 212002, China
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Besançon, 25030, France
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Lille, 59000, France
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Lyon, 69008, France
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Montpellier, 34070, France
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Reims, 51100, France
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Rouen, 76031, France
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Strasbourg, 67033, France
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Villejuif, 94805, France
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Bunkyō City, 113-8431, Japan
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Chūōku, 104-0045, Japan
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Hidaka-shi, 350-1298, Japan
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Hirakata-shi, 573-1191, Japan
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Hiroshima, 730-8518, Japan
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Kashiwa, 277-8577, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Maebashi, 371-8511, Japan
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Matsuyama, 791-0280, Japan
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Niigata, 951-8566, Japan
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Okayama, 700-8558, Japan
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Osaka, 541-8567, Japan
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Osaka, 545-8586, Japan
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Ota-shi, 373-8550, Japan
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Sendai, 980-8574, Japan
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Shinagawa-ku, 142-8666, Japan
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Yokohama, 232-0024, Japan
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Yokohama, 241-8515, Japan
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Chihuahua City, 31210, Mexico
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Cuernavaca, 62290, Mexico
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Mérida, 97134, Mexico
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Monterrey, 66220, Mexico
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Veracruz, 91851, Mexico
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Katowice, 40-074, Poland
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Krakow, 31-115, Poland
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Lodz, 90-513, Poland
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Siedlce, 08-110, Poland
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Warsaw, 02-034, Poland
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Chelyabinsk, 454087, Russia
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Krasnodar, 350040, Russia
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Moscow, 115478, Russia
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Obninsk, 249031, Russia
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Saint Petersburg, 197758, Russia
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Tyumen, 6250041, Russia
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Ufa, 450054, Russia
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Yekaterinburg, 620905, Russia
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Daegu, 41404, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 138-736, South Korea
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Suwon, 16247, South Korea
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Barcelona, 8035, Spain
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Córdoba, 14004, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Madrid, 28046, Spain
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Pamplona, 31008, Spain
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Santander, 39008, Spain
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Zaragoza, 50009, Spain
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Changhua, 50006, Taiwan
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 82445, Taiwan
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Kaohsiung City, 83301, Taiwan
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Taichung, 40443, Taiwan
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Taichung, 407, Taiwan
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Tainan, 710, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan District, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10300, Thailand
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Chanthaburi, 22000, Thailand
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Chiang Mai, 50200, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Ankara, 06800, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Erzurum, 25240, Turkey (Türkiye)
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Goztepe Istanbul, Turkey (Türkiye)
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Izmir, 35575, Turkey (Türkiye)
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Van, 65080, Turkey (Türkiye)
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, Vietnam

Conditions

Explore the condition pages connected to this study.

ESOPHAGEAL SQUAMOUS CELL CARCINOMA