Immunotherapy combo tested for tough thyroid cancers
NCT ID NCT03753919
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase II trial tested two immunotherapy drugs, durvalumab and tremelimumab, in 79 patients with advanced thyroid cancer that had progressed despite treatment. The goal was to see if the combination could slow or stop cancer growth. The study was terminated early, so the full results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- durvalumab and tremelimumab (immunotherapy drugs)
- What this could lead to
- If successful, this combination could offer a new treatment option for patients with advanced thyroid cancer that has stopped responding to standard therapies.
- What could go wrong
- The trial was terminated early, so results are limited. Immunotherapy can cause immune-related side effects, and the combination may not work for all thyroid cancer types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clínica Universidad de Navarra
Pamplona, Spain
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Complejo Hospitalario Universitario de Vigo (CHUVI)
Vigo, 36036, Spain
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Hospital Clínic Barcelona
Barcelona, Spain
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Hospital Clínico San Carlos
Madrid, Spain
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Hospital General Universitario Morales Meseguer
Murcia, Spain
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Hospital Provincial de Castellón
Castellon, Valencia, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Spain
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Hospital Universitario 12 de Octubre
Madrid, Spain
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Hospital Universitario HM Sanchinarro
Madrid, Spain
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Hospital Universitario La Paz
Madrid, Spain
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Hospital Universitario Ramón y Cajal
Madrid, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, Spain
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Instituto Catalán de Oncología de Hospitalet
L'Hospitalet de Llobregat, Barcelona, 08908, Spain
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Instituto Valenciano de Oncología
Valencia, 46009, Spain
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MD Anderson Cancer Center
Madrid, 28033, Spain
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