New hope for frail lung cancer patients: immune drug may delay tumor growth
NCT ID NCT05617963
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests whether the immune-boosting drug durvalumab can help frail patients with limited-stage small cell lung cancer keep their disease from progressing after standard chemoradiotherapy. About 100 participants who have stable or improved disease after initial treatment will receive durvalumab every 4 weeks for up to 24 months. The study focuses on patients who are older, have a weaker performance status, or could not receive full concurrent chemoradiation due to other health issues.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- durvalumab (a drug that helps the immune system fight cancer)
- What this could lead to
- If it works, this could offer a way to keep lung cancer from worsening in frail patients who have limited treatment options.
- What could go wrong
- This is a small, early-phase trial with only 100 participants. The drug may not improve survival and could cause side effects like immune-related inflammation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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APHM - Hôpital Nord
Marseille, France
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CARIO
Plérin, France
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CH Saint Brieuc
Saint-Brieuc, France
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CH de la côte Basque
Bayonne, France
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CHI Créteil
Créteil, France
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CHU Dupuytren
Limoges, France
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CHU de CAEN
Caen, France
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Centre François Baclesse
Caen, France
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Centre George François Leclerc
Dijon, France
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Centre Henri Becquerel
Rouen, France
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Centre Hospitalier du Pays d'Aix
Aix-en-Provence, France
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Centre Jean Perrin
Clermont-Ferrand, France
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Centre Lacassagne
Nice, France
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Centre Léon Bérard
Lyon, France
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Centre Oscar Lambret
Lille, France
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Centre d'Oncologie du Pays Basque
Bayonne, France
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Centre d'oncologie Saint Yves
Vannes, France
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Centre de Radiothérapie du Pays d'Aix
Aix-en-Provence, France
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Clinique Belharra
Bayonne, France
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Clinique Mutualiste de l'Estuaire
Saint-Nazaire, France
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Groupe Hospitalier Bretagne Sud
Lorient, France
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Hopital Nord Ouest - Villefranche sur Saône
Villefranche-sur-Saône, France
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Hopital européen Marseille
Marseille, France
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Hopital privé Clairval
Marseille, France
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Hopital privé du Confluent
Nantes, France
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Hôpital Tenon APHP
Paris, France
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Institut Curie
Paris, France
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Institut Godinot
Reims, France
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Institut Paoli-Calmettes
Marseille, France
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Institut du Cancer Avignon-Provence
Avignon, France
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Institut régional du Cancer de Montpellier - ICM Val d'Aurelle
Montpellier, France
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Polyclinique de Limoges -Site Clinique Chénieux
Limoges, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Chemo-Immunotherapy duo outsmart tough lung cancer?
- Can head radiation stop lung cancer from spreading to the brain?
- New hope for tough lung cancer: drug plus radiation combo shows promise in early trial
- New hope for hard-to-treat cancers? experimental combo enters phase 2 trial
- New hope for tough lung cancer: early trial launches in china
- Laser and Light-Sensitive drug shrink lung tumors in early trial