Advanced imaging study tests asthma Drug's impact on lungs

NCT ID NCT04400318

Completed Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

Summary

This study tested whether the drug dupilumab reduces lung inflammation and mucus buildup in adults with moderate-to-severe asthma. 109 participants received either dupilumab or a placebo for 24 weeks. Researchers used detailed lung scans and breathing tests to measure changes in airway inflammation, mucus plugs, and lung function.

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Contacts and locations

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Locations

Allianz Research Institute Site Number : 8400020

Westminster, California, 92683, United States
American Health Research Site Number : 8400005

Charlotte, North Carolina, 28277, United States
Investigational Site Number : 1000002

Sofia, 1680, Bulgaria
Investigational Site Number : 1000003

Sofia, 1233, Bulgaria
Investigational Site Number : 1000004

Montana, 3403, Bulgaria
Investigational Site Number : 1000005

Sofia, 1202, Bulgaria
Investigational Site Number : 1000006

Sofia, 1233, Bulgaria
Investigational Site Number : 1000007

Stara Zagora, 6001, Bulgaria
Investigational Site Number : 1000008

Rousse, 7002, Bulgaria
Investigational Site Number : 1000010

Sofia, 1431, Bulgaria
Investigational Site Number : 1000011

Sofia, 1407, Bulgaria
Investigational Site Number : 1000012

Plovdiv, 4002, Bulgaria
Investigational Site Number : 1000013

Dupnitsa, 2600, Bulgaria
Investigational Site Number : 1000015

Sofia, 1000, Bulgaria
Investigational Site Number : 1000018

Plovdiv, 4000, Bulgaria
Investigational Site Number : 1580001

Taipei, 110, Taiwan
Investigational Site Number : 1580002

Taichung, 40447, Taiwan
Investigational Site Number : 1580003

Tainan, 704, Taiwan
Investigational Site Number : 1580004

Kaohsiung City, 807, Taiwan
Investigational Site Number : 2080001

Hvidovre, 2650, Denmark
Investigational Site Number : 2080002

Copenhagen, 2100, Denmark
Investigational Site Number : 2080003

Copenhagen Nv, 2400, Denmark
Investigational Site Number : 2080006

Aarhus N, 8200, Denmark
Investigational Site Number : 2500001

Montpellier, France
Investigational Site Number : 3800001

Pisa, 56124, Italy
Investigational Site Number : 3800003

Cona, Ferrara, 44124, Italy
Investigational Site Number : 3800004

Rozzano, Milano, 20089, Italy
Investigational Site Number : 6200001

Porto, 4202-451, Portugal
Investigational Site Number : 6200003

Porto, 4100-180, Portugal
Investigational Site Number : 6200004

Coimbra, 3000-075, Portugal
Investigational Site Number : 6200005

Guimarães, 4810-061, Portugal
Investigational Site Number : 6200006

Lisbon, 1649-035, Portugal
Investigational Site Number : 6420001

Cluj-Napoca, 400371, Romania
Investigational Site Number : 6420003

Timișoara, 300134, Romania
Investigational Site Number : 6420005

Bragadiru, 769764, Romania
Investigational Site Number : 6420006

Cluj-Napoca, 400275, Romania
Investigational Site Number : 6420007

Oradea, 410155, Romania
Investigational Site Number : 6420008

Brasov, 500283, Romania
Investigational Site Number : 6820001

Riyadh, 11525, Saudi Arabia
Investigational Site Number : 6820002

Riyadh, 12372, Saudi Arabia
Investigational Site Number : 6820004

Jeddah, 21423, Saudi Arabia
Investigational Site Number : 6820006

Riyadh, 11426, Saudi Arabia
Investigational Site Number : 6820008

Dammam, 31952, Saudi Arabia
Investigational Site Number : 6820010

Riyadh, 12746, Saudi Arabia
Investigational Site Number : 7240001

Barcelona, Barcelona [Barcelona], 08035, Spain
Investigational Site Number : 7240002

Santiago de Compostela, Galicia [Galicia], 15706, Spain
Investigational Site Number : 7240003

Madrid, Madrid, Comunidad de, 28046, Spain
Investigational Site Number : 7240005

Madrid, Madrid, Comunidad de, 28041, Spain
Investigational Site Number : 7520001

Lund, 221 85, Sweden
Investigational Site Number : 8040001

Ivano-Frankivsk, 76018, Ukraine
Investigational Site Number : 8040002

Kharkiv, 61124, Ukraine
Investigational Site Number : 8040003

Chernivtsi, 58001, Ukraine
Investigational Site Number : 8040004

Kyiv, 01023, Ukraine
Investigational Site Number : 8040005

Odesa, 65025, Ukraine
Investigational Site Number : 8040007

Ternopil, 46000, Ukraine
Investigational Site Number : 8260001

Leicester, Leicestershire, LE3 9QP, United Kingdom
Investigational Site Number : 8260002

Bradford, BD9 6RJ, United Kingdom
Medical University of South Carolina - Pulmonary & Critical Care Clinical Research Program Site Number : 8400009

Charleston, South Carolina, 29425, United States
The Lung Research Center Site Number : 8400010

Chesterfield, Missouri, 63017, United States
University of Kansas School of Medicine Site Number : 8400008

Kansas City, Kansas, 66103, United States
University of Michigan Site Number : 8400002

Ann Arbor, Michigan, 48109, United States
Velocity Clinical Research, Medford Site Number : 8400014

Medford, Oregon, 97504, United States
VitaLink Research - Spartanburg Site Number : 8400011

Spartanburg, South Carolina, 29303, United States
VitaLink Research-Greenville Site Number : 8400013

Greenville, South Carolina, 29615, United States
~Spartanburg Medical Research Site Number : 8400004

Spartanburg, South Carolina, 29303, United States

Conditions

Explore the condition pages connected to this study.

ASTHMA