Gene-Guided asthma treatment may cut attacks in half

NCT ID NCT03694158

First seen Feb 26, 2026 · Last updated May 15, 2026 · Updated 6 times

Summary

This study looks at whether people aged 12 and older with a specific gene change (IL-4RαR576) get more relief from the asthma drug dupilumab. Over 48 weeks, researchers track how many severe asthma attacks occur compared to a placebo. The goal is to see if genetic testing can help personalize asthma care.

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Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • MetroHealth System

    Cleveland, Ohio, 44109, United States

  • Montefiore Einstein Clinical Research Center

    The Bronx, New York, 10467, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

Conditions

Explore the condition pages connected to this study.