New pill takes on tough cancers in first human trial

NCT ID NCT07189403

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests an oral drug called DS9051b in 40 people with advanced adrenocortical carcinoma or metastatic castration-resistant prostate cancer. The main goal is to check safety and find the right dose, while also looking for any signs that the drug might shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DS9051b (oral drug)
What this could lead to: If it works, this could point toward a new treatment option for advanced adrenal or prostate cancers that have stopped responding to other therapies.
What could go wrong: This is a very early, small Phase 1 trial focused on safety, not proof of effectiveness. The drug may not shrink tumors or may cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adrenal carcinoma adrenal cortex carcinoma castration-resistant prostate carcinoma metastatic prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED OR METASTATIC ADRENOCORTICAL CARCINOMA METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Brown University
RECRUITING

Providence, Rhode Island, 02903, United States
Centre Oscar Lambret
NOT_YET_RECRUITING

Villejuif, 94800, France
Columbia University
RECRUITING

New York, New York, 10032, United States
Florida Cancer Specialists
RECRUITING

Sarasota, Florida, 34232, United States
Oncopole Claudius Regaud
RECRUITING

Toulouse, 31100, France
Royal Marsden
NOT_YET_RECRUITING

London, SW3 6JJ, United Kingdom

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