Can antibiotics trigger Kidney-Harming crystals? a study investigates
NCT ID NCT07772752
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This study looks at hospitalized patients receiving certain antibiotics—sulfamethoxazole, high-dose ciprofloxacin, or high-dose intravenous amoxicillin—to see how often they develop crystals in their urine and whether this is linked to acute kidney injury. Researchers will examine urine samples at several time points during treatment and track kidney function through blood tests. The goal is to better understand and potentially prevent antibiotic-related kidney damage.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Crystalluria examination (microscopic urine test)
- What this could lead to
- If this study succeeds, it could help doctors predict and prevent kidney damage from certain antibiotics, improving patient safety.
- What could go wrong
- This is an observational study, so it cannot prove cause and effect. Results may vary by patient and may not apply to all settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 290 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Able to give informed consent without the intervention of a legal representative * Treatment with * sulfamethoxazole/trimethoprim, with minimum dose of * ≥ 800/160 mg q12h oral administration (PO) or intravenous administration (IV) for eGFR ≥ 30 ml/min * ≥ 400/80 mg q12h OR or IV for eGFR \< 30 ml/min OR * high dose ciprofloxacin, defined as * ≥ 750 mg q12h PO or ≥ 400 mg q8h IV for eGFR ≥ 60 ml/min * ≥ 750 mg q24h PO or ≥ 400 mg q12h IV for eGFR 15-59 m/min * ≥ 750 mg q24h PO OR ≥ 400 mg q24h IV for eGFR \< 15 ml/min OR * high dose amoxicillin, defined as * ≥ 2g q6h IV for eGFR ≥ 30 ml/min * ≥ 2g q8h IV for eGFR 15-29 ml/min * ≥ 2g q12h IV for eGFR \< 15 ml/min * Treatment for min 24 hours and sufficiently long to perform one crystalluria investigation as defined in the protocol * Baseline renal function up to 72 hours prior to the start of antibiotic treatment available (evaluated by serum creatinine and eGFR (CKD-EPI)) for all study groups and additional serum urea for the sulfamethoxazole group). Exclusion Criteria: * Unable to give informed consent without the intervention of a legal representative * No baseline renal function up to 72 hours prior to the start of antibiotic treatment available, evaluated by serum creatinine and eGFR (CKD-EPI)) for all study groups and additional serum urea for the sulfamethoxazole group. * Treatment duration \< 24 hours or insufficiently long to perform one crystalluria inves-tigation as defined in the protocol * Patients treated with hemodialysis or peritoneal dialysis, anuric patients before start of antibiotic treatment * Patients with urinary diversions
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Universitair Ziekenhuis Brussel
RECRUITINGBrussels, 1090, Belgium