New heart valve clip could spare patients from Open-Heart surgery

NCT ID NCT05927441

Recruiting now Disease control Sponsor: Hangzhou Valgen Medtech Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests the DragonFly device, a clip that repairs leaky mitral valves without open-heart surgery. It enrolls 168 people with moderate-to-severe mitral regurgitation who are too high-risk for surgery. The goal is to see if the device safely controls the leak and reduces heart failure symptoms over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DragonFly Transcatheter Mitral Valve Repair System (a device that clips the mitral valve to stop leakage)
What this could lead to: If successful, this device could offer a less invasive way to control mitral regurgitation and reduce heart failure symptoms without open-heart surgery.
What could go wrong: This is an early-stage study with no control group, so results may not prove superiority over existing treatments. Risks include procedural complications, device failure, or no improvement in heart function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

mitral valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MITRAL VALVE INSUFFICIENCY

Contacts and locations

Locations

Universitatsklinikum Bonn Medizinische Klinik und Poliklinik
RECRUITING

Bonn, Germany

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