New hope for advanced endometrial cancer: immunotherapy trial aims to extend survival
NCT ID NCT05201547
Summary
This large, late-stage trial is testing whether adding the immunotherapy drug dostarlimab to standard chemotherapy works better than chemotherapy alone for women with advanced or recurrent endometrial cancer that has a specific genetic marker (MMR deficient). The main goal is to see if the combination helps control the cancer for a longer time without it getting worse. The study will also closely monitor side effects and quality of life.
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Contacts and locations
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Locations
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AP-HP Hôpital Pitié-Salpêtrière
Paris, 75013, France
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APHM - Hôpital de la Timone
Marseille, 13005, France
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Addenbrooke's Hospital
Cambridge, CB2 0QQ GB, United Kingdom
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Asan Medical Center
Seoul, 05505, South Korea
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Auckland City Hospital
Auckland, 1023, New Zealand
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Azienda Sanitaria Universitaria Friuli Centrale
Udine, 33100, Italy
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CH Simone Veil de Beauvais
Beauvais, 60000, France
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CHI de Cornouaille
Quimper, France
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CHRU Jean Minjoz
Besançon, 25000, France
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CHU Brest
Brest, France
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CHU Bretonneau
Tours, France
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CHU Saint-Etienne - Pôle de Cancérologie
Saint-Etienne, 42055, France
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CHU Strasbourg - Hôpital de Hautepierre
Strasbourg, France
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CHU d'Amiens - Hôpital Sud
Amiens, 80054, France
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CHU d'ORLEANS
Orléans, France
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CHU de Dijon
Dijon, 21079, France
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CHU de Poitiers - Hôpital de la Milétrie
Poitiers, 86021, France
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Calvary Mater Newcastle
Waratah, 2298, Australia
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Canberra Hospital
Garran, 2605, Australia
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Centre Antoine Lacassagne
Nice, 06100, France
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Centre Azuréen de Cancérologie
Mougins, 06250, France
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Centre CARIO - HPCA
Plérin, 22190, France
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Centre Eugène Marquis
Rennes, 35042, France
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Centre François Baclesse
Caen, 14000, France
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Centre Georges François Leclerc
Dijon, 21000, France
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Centre Henri Becquerel
Rouen, 76038, France
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Centre Hospitalier Général de Pau
Pau, 64046, France
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Centre Hospitalier Intercommunal de Créteil
Créteil, 21079, France
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Centre Hospitalier Lyon Sud
Lyon, 69310, France
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Centre Hospitalier Privé de Saint-Grégoire
Saint-Grégoire, 35760, France
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Centre Hospitalier William Morey
Chalon-sur-Saône, 71100, France
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Centre Hospitalier d'Auxerre
Auxerre, 89011, France
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Centre Jean Perrin
Clermont-Ferrand, 63000, France
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Centre Léon Bérard
Lyon, 69373, France
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Centre Oscar Lambret
Lille, 59020, France
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Centro di Riferimento Oncologico
Aviano, 3308, Italy
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Clinique Victor Hugo
Le Mans, 72000, France
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Clinique de l'Europe
Amiens, 80090, France
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Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, 00168, Italy
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Fukushima Medical University Hospital
Fukushima, 960-1295, Japan
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GHPSO
Creil, 60109, France
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Groupe Hospitalier Diaconesses-Croix Saint-Simon
Paris, 75020, France
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Hospital Clínico Universitario Santiago de Compostela
Santiago de Compostela, 15706, Spain
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Hospital General Universitario de Elche
Elche, Alicante, 30203, Spain
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Hospital Germans Trias i Pujol / ICO Badalona
Badalona, 08916, Spain
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Hospital Son Llátzer
Palma de Mallorca, 07198, Spain
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Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
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Hospital Universitario Reina Sofia
Córdoba, 14004, Spain
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Hospital Universitario Son Espases
Palma, 07120, Spain
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Hospital Universitario de León
León, 24008, Spain
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Hospital Universitario y Politécnico La Fe
Valencia, 46026, Spain
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Hôpital Cochin
Paris, 75014, France
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Hôpital Européen Georges Pompidou
Paris, France
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Hôpital Privé du Confluent S.A.S.
Nantes, 44000, France
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Hôpital Saint-Joseph
Marseille, 13285, France
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Hôpital de Mont-de-Marsan
Mont-de-Marsan, France
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ICL - Centre Alexis Vautrin
Vandœuvre-lès-Nancy, 54511, France
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ICM Val d'Aurelle
Montpellier, 34298, France
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ICO - Centre René Gauducheau
Saint-Herblain, 44805, France
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ICO Paul Papin
Angers, 49055, France
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IRCCS Istituto Oncologico Giovanni Paolo II
Bari, 70124, Italy
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IRCCS Ospedale San Raffaele
Milan, 20132, Italy
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Institut Bergonié
Bordeaux, 33076, France
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Institut Curie
Paris, 75005, France
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Institut Gustave Roussy
Villejuif, 94805, France
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Institut Jean Godinot
Reims, France
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Institut Mutualiste Montsouris
Paris, France
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Institut Paoli Calmettes
Marseille, 13273, France
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Institut Sainte Catherine
Avignon, France
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Institut de Cancérologie de Strasbourg Europe - ICANS
Strasbourg, 67200, France
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Institut de cancérologie du gard
Nîmes, 30029, France
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Istituto Europeo di Oncologia
Milan, 20141, Italy
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Korea University Guro Hospital
Seoul, 08308, South Korea
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Kurume University Hospital
Fukuoka, 830-0011, Japan
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Médipôle de NANCY SAS
Nancy, France
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National Cancer Center
Gyeonggi-do, 10408, South Korea
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National Cancer Centre Singapore (NCCS)
Singapore, 169610, Singapore
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National University Hospital (NUH)
Singapore, 119074, Singapore
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Northampton General Hospital NHS Trust
Northampton, NN1 5BD GB, United Kingdom
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Oncopole Claudius Regaud - IUCT Oncopole
Toulouse, 31059, France
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Ospedale "Santa Maria delle Croci"
Ravenna, 48121, Italy
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Ospedale "Umberto I"
Lugo, 48022, Italy
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Ospedale Civile degli Infermi
Faenza, 48018, Italy
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Ospedale San Luca
Lucca, 55100, Italy
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Ospedale degli Infermi
Biella, 13875, Italy
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Policlinco Umberto I
Roma, 00161, Italy
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Princess Margaret Cancer Centre
Toronto, M5G2M9, Canada
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Queen Elizabeth Hospital
Birmingham, B15 2GW GB, United Kingdom
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ROC 37
Chambray-lès-Tours, France
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Royal Cornwall Hospital
Truro, 3LJ GB, United Kingdom
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Saitama Medical University International Medical Center
Saitama, 350-1298, Japan
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Samsung Medical Center
Seoul, 06351, South Korea
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Seoul National University Bundang Hospital
Gyeonggi-do, 13620, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Spedali Civili-Università di Brescia
Brescia, 25123, Italy
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The Cancer Institute Hospital Of JFCR
Kōtoku, 135-8550, Japan
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University College London Hospital
London, NW1 2PG GB, United Kingdom
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Western General Hospital
Edinburgh, EH42XU, United Kingdom
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Yonsei Medical Center Severance Hospital
Seoul, 03722, South Korea
Conditions
Explore the condition pages connected to this study.