New hope for advanced endometrial cancer: immunotherapy trial aims to extend survival

NCT ID NCT05201547

Summary

This large, late-stage trial is testing whether adding the immunotherapy drug dostarlimab to standard chemotherapy works better than chemotherapy alone for women with advanced or recurrent endometrial cancer that has a specific genetic marker (MMR deficient). The main goal is to see if the combination helps control the cancer for a longer time without it getting worse. The study will also closely monitor side effects and quality of life.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AP-HP Hôpital Pitié-Salpêtrière

    Paris, 75013, France

  • APHM - Hôpital de la Timone

    Marseille, 13005, France

  • Addenbrooke's Hospital

    Cambridge, CB2 0QQ GB, United Kingdom

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Auckland City Hospital

    Auckland, 1023, New Zealand

  • Azienda Sanitaria Universitaria Friuli Centrale

    Udine, 33100, Italy

  • CH Simone Veil de Beauvais

    Beauvais, 60000, France

  • CHI de Cornouaille

    Quimper, France

  • CHRU Jean Minjoz

    Besançon, 25000, France

  • CHU Brest

    Brest, France

  • CHU Bretonneau

    Tours, France

  • CHU Saint-Etienne - Pôle de Cancérologie

    Saint-Etienne, 42055, France

  • CHU Strasbourg - Hôpital de Hautepierre

    Strasbourg, France

  • CHU d'Amiens - Hôpital Sud

    Amiens, 80054, France

  • CHU d'ORLEANS

    Orléans, France

  • CHU de Dijon

    Dijon, 21079, France

  • CHU de Poitiers - Hôpital de la Milétrie

    Poitiers, 86021, France

  • Calvary Mater Newcastle

    Waratah, 2298, Australia

  • Canberra Hospital

    Garran, 2605, Australia

  • Centre Antoine Lacassagne

    Nice, 06100, France

  • Centre Azuréen de Cancérologie

    Mougins, 06250, France

  • Centre CARIO - HPCA

    Plérin, 22190, France

  • Centre Eugène Marquis

    Rennes, 35042, France

  • Centre François Baclesse

    Caen, 14000, France

  • Centre Georges François Leclerc

    Dijon, 21000, France

  • Centre Henri Becquerel

    Rouen, 76038, France

  • Centre Hospitalier Général de Pau

    Pau, 64046, France

  • Centre Hospitalier Intercommunal de Créteil

    Créteil, 21079, France

  • Centre Hospitalier Lyon Sud

    Lyon, 69310, France

  • Centre Hospitalier Privé de Saint-Grégoire

    Saint-Grégoire, 35760, France

  • Centre Hospitalier William Morey

    Chalon-sur-Saône, 71100, France

  • Centre Hospitalier d'Auxerre

    Auxerre, 89011, France

  • Centre Jean Perrin

    Clermont-Ferrand, 63000, France

  • Centre Léon Bérard

    Lyon, 69373, France

  • Centre Oscar Lambret

    Lille, 59020, France

  • Centro di Riferimento Oncologico

    Aviano, 3308, Italy

  • Clinique Victor Hugo

    Le Mans, 72000, France

  • Clinique de l'Europe

    Amiens, 80090, France

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Roma, 00168, Italy

  • Fukushima Medical University Hospital

    Fukushima, 960-1295, Japan

  • GHPSO

    Creil, 60109, France

  • Groupe Hospitalier Diaconesses-Croix Saint-Simon

    Paris, 75020, France

  • Hospital Clínico Universitario Santiago de Compostela

    Santiago de Compostela, 15706, Spain

  • Hospital General Universitario de Elche

    Elche, Alicante, 30203, Spain

  • Hospital Germans Trias i Pujol / ICO Badalona

    Badalona, 08916, Spain

  • Hospital Son Llátzer

    Palma de Mallorca, 07198, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, 14004, Spain

  • Hospital Universitario Son Espases

    Palma, 07120, Spain

  • Hospital Universitario de León

    León, 24008, Spain

  • Hospital Universitario y Politécnico La Fe

    Valencia, 46026, Spain

  • Hôpital Cochin

    Paris, 75014, France

  • Hôpital Européen Georges Pompidou

    Paris, France

  • Hôpital Privé du Confluent S.A.S.

    Nantes, 44000, France

  • Hôpital Saint-Joseph

    Marseille, 13285, France

  • Hôpital de Mont-de-Marsan

    Mont-de-Marsan, France

  • ICL - Centre Alexis Vautrin

    Vandœuvre-lès-Nancy, 54511, France

  • ICM Val d'Aurelle

    Montpellier, 34298, France

  • ICO - Centre René Gauducheau

    Saint-Herblain, 44805, France

  • ICO Paul Papin

    Angers, 49055, France

  • IRCCS Istituto Oncologico Giovanni Paolo II

    Bari, 70124, Italy

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • Institut Bergonié

    Bordeaux, 33076, France

  • Institut Curie

    Paris, 75005, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut Jean Godinot

    Reims, France

  • Institut Mutualiste Montsouris

    Paris, France

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Institut Sainte Catherine

    Avignon, France

  • Institut de Cancérologie de Strasbourg Europe - ICANS

    Strasbourg, 67200, France

  • Institut de cancérologie du gard

    Nîmes, 30029, France

  • Istituto Europeo di Oncologia

    Milan, 20141, Italy

  • Korea University Guro Hospital

    Seoul, 08308, South Korea

  • Kurume University Hospital

    Fukuoka, 830-0011, Japan

  • Médipôle de NANCY SAS

    Nancy, France

  • National Cancer Center

    Gyeonggi-do, 10408, South Korea

  • National Cancer Centre Singapore (NCCS)

    Singapore, 169610, Singapore

  • National University Hospital (NUH)

    Singapore, 119074, Singapore

  • Northampton General Hospital NHS Trust

    Northampton, NN1 5BD GB, United Kingdom

  • Oncopole Claudius Regaud - IUCT Oncopole

    Toulouse, 31059, France

  • Ospedale "Santa Maria delle Croci"

    Ravenna, 48121, Italy

  • Ospedale "Umberto I"

    Lugo, 48022, Italy

  • Ospedale Civile degli Infermi

    Faenza, 48018, Italy

  • Ospedale San Luca

    Lucca, 55100, Italy

  • Ospedale degli Infermi

    Biella, 13875, Italy

  • Policlinco Umberto I

    Roma, 00161, Italy

  • Princess Margaret Cancer Centre

    Toronto, M5G2M9, Canada

  • Queen Elizabeth Hospital

    Birmingham, B15 2GW GB, United Kingdom

  • ROC 37

    Chambray-lès-Tours, France

  • Royal Cornwall Hospital

    Truro, 3LJ GB, United Kingdom

  • Saitama Medical University International Medical Center

    Saitama, 350-1298, Japan

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Seoul National University Bundang Hospital

    Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Spedali Civili-Università di Brescia

    Brescia, 25123, Italy

  • The Cancer Institute Hospital Of JFCR

    Kōtoku, 135-8550, Japan

  • University College London Hospital

    London, NW1 2PG GB, United Kingdom

  • Western General Hospital

    Edinburgh, EH42XU, United Kingdom

  • Yonsei Medical Center Severance Hospital

    Seoul, 03722, South Korea

Conditions

Explore the condition pages connected to this study.