New drug aims to stop CIDP relapses in its tracks

NCT ID NCT06858579

Recruiting now Disease control Sponsor: Dianthus Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether the drug claseprubart (DNTH103) can prevent relapses in adults with CIDP, a nerve disorder that causes weakness and disability. About 256 participants will receive either the drug or a placebo. The main goal is to see how long it takes for symptoms to worsen, with a focus on safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

claseprubart (DNTH103)

What this could lead to

If successful, this could provide a new treatment option to control CIDP and reduce relapses, helping patients maintain function and independence.

What could go wrong

This is still an experimental drug. Even in Phase 3, it may not prove better than placebo, and side effects are possible. Results may not apply to all CIDP patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chronic inflammatory demyelinating polyradiculoneuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Cinical Study Site
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Lebanon, New Hampshire, 03766, United States
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Nashville, Tennessee, 37232, United States
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Houston, Texas, 77030, United States
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Buenos Aires, Buenos Aires, Argentina
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Rosario, Santa Fe Province, Argentina
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Liverpool, New South Wales, Australia
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Saint Leonards, New South Wales, 2065, Australia
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Sydney, New South Wales, 2033, Australia
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Southport, Queensland, 4215, Australia
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Anderlecht, Brussels Capital, Belgium
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Brussels, Belgium
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Rio de Janeiro, Rio de Janeiro, 20551-030, Brazil
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Natal, Brazil
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Porto Alegre, 90610-000, Brazil
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Salvador, 40290-000, Brazil
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São Paulo, 04038, Brazil
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São Paulo, 05403-000, Brazil
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Sofia, Bulgaria
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Medellín, Antioquia, Colombia
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Antioquia, Colombia
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Medellín, Colombia
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Osijek, Croatia
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Brest, 29200, France
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Tours, 37000, France
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München, Bavaria, Germany
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Greifswald, 17489, Germany
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Beersheba, Israel
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Haifa, 3109601, Israel
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Safed, Israel
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Genova, 16132, Italy
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Gussago, 25064, Italy
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Milan, 20126, Italy
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Milan, Italy
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Modena, Italy
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Roma, 00133, Italy
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Terni, Italy
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Riga, LV-1002, Latvia
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Kota Kinabalu, Sabah, Malaysia
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Kuching, Sarawak, Malaysia
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George Town, 11700, Malaysia
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Johor Bahru, 80100, Malaysia
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Kota Kinabalu, Malaysia
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Kuala Lumpur, 50586, Malaysia
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Kuala Lumpur, 50603, Malaysia
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Kuala Lumpur, 56000, Malaysia
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Kuching, Malaysia
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Sungai Buloh, Malaysia
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Amsterdam, Netherlands
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Utrecht, Netherlands
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Cebu City, Philippines
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City of Muntinlupa, Philippines
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Iloilo City, Philippines
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Warsaw, 04-141, Poland
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Târgu Mureş, 540136, Romania
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Belgrade, 11000, Serbia
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Daegu, South Korea
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Daejeon, South Korea
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Seoul, South Korea
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Uijeongbu-si, South Korea
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Yangsan, South Korea
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Barcelona, 08041, Spain
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Bangkok, Thailand
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Hat Yai, Thailand
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Khlong Luang, Thailand
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Khon Kaen, 40002, Thailand
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Khon Kaen, Thailand
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Manchester, England, United Kingdom
Cinical Study Site #2
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San Miguel de Tucumán, Argentina
Cinical Study Site #2
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Seoul, South Korea
Cinical Study Site #2
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Bangkok, Thailand
Cinical Study Site #3
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Buenos Aires, Argentina
Cinical Study Site #3
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Seoul, South Korea
Cinical Study Site #4
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Buenos Aires, Argentina
Clinical Study Site
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Birmingham, Alabama, 35294, United States
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Phoenix, Arizona, 85028, United States
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Scottsdale, Arizona, 85251', United States
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Los Angeles, California, 90048, United States
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San Francisco, California, 94109, United States
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San Francisco, California, 94158, United States
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Washington D.C., District of Columbia, 20007, United States
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Maitland, Florida, 32751, United States
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Tampa, Florida, 33620, United States
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Honolulu, Hawaii, 96817, United States
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Chicago, Illinois, 60611, United States
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Edwardsville, Illinois, 62025, United States
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Indianapolis, Indiana, 46202, United States
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Kansas City, Kansas, 66160, United States
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Burlington, Massachusetts, 01805, United States
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East Lansing, Michigan, 48824, United States
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Omaha, Nebraska, 68198, United States
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New York, New York, 10021, United States
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New York, New York, 10032, United States
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Cincinnati, Ohio, 45219, United States
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Columbus, Ohio, 43221, United States
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Portland, Oregon, 97239, United States
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Dallas, Texas, 75243, United States
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Denton, Texas, 76208, United States
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Round Rock, Texas, 78681, United States
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Sugar Land, Texas, 77478, United States
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Seattle, Washington, 98195, United States
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Buenos Aires, Argentina
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San Miguel de Tucumán, Argentina
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Randwick, New South Wales, 2031, Australia
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Melbourne, Victoria, 3004, Australia
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Campinas, São Paulo, Brazil
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Sofia, Bulgaria
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Hefei, Anhui, 230001, China
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Guangzhou, Guangdong, 510080, China
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Changsha, Hu'Nan, 410008, China
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Changsha, Hu'Nan, 410013, China
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Wuhan, Hubei, 430060, China
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Chifeng, Inner Mongolia, 024050, China
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Suzhou, Jiangsu, 215006, China
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Beijing, 100034, China
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Beijing, 100191, China
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Chengdu, 610072, China
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Fujian, 350001, China
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Guangdong, 510180, China
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Guangzhou, 510515, China
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Jilin City, 130021, China
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Shanghai, 200031, China
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Shanghai, 200040, China
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Sichuan, 610072, China
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Taiyuan, China
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Wuhan, China
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Aarhus, 8200, Denmark
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Copenhagen, Denmark
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Bordeaux, 33000, France
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Bron, 69500, France
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Clermont-Ferrand, 63000, France
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Libourne, 33500, France
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Marseille, 13005, France
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Nice, 06000, France
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Paris, 75013, France
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Paris, 75610, France
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Strasbourg, 67200, France
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Tours, 37000, France
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Tbilisi, Georgia
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Sande, Lower Saxony, 26452, Germany
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Aachen, 52074, Germany
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Rüdersdorf, 15562, Germany
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Sande, 26452, Germany
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Bergamo, 24127, Italy
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Bologna, 40139, Italy
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Pavia, 27100, Italy
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Ponderano, 13875, Italy
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Roma, 00128, Italy
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Roma, Italy
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Riga, LV-1024, Latvia
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Skopje, 1000, North Macedonia
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Bydgoszcz, 85-090, Poland
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Krakow, 30-688, Poland
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Lublin, 20-701, Poland
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Lublin, 20-718, Poland
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Lublin, 7763138, Poland
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Wroclaw, 50-367, Poland
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Bucharest, 050474, Romania
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Belgrade, 11000, Serbia
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Kragujevac, 34000, Serbia
Clinical Study Site
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Niš, 18000, Serbia
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Barcelona, Barcelona, 08916, Spain
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Alicante, 03010, Spain
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Barcelona, 08025, Spain
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Bilbao, 48013, Spain
Clinical Study Site
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Oxford, United Kingdom
Clinical Study Site #2
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Buenos Aires, Argentina
Clinical Study Site #2
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Roma, 00189, Italy
Texas Locations
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Houston, Texas, 77054, United States