New Alzheimer's drug enters early human testing

NCT ID NCT07328451

Recruiting now Disease control Sponsor: Denali Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study is testing an experimental drug called DNL628 in people with early-stage Alzheimer's disease. The main goal is to see if the drug is safe and how the body processes it. About 68 participants will receive either DNL628 or a placebo. This is an early-phase trial, so it focuses on safety rather than proving the drug works.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease early-onset autosomal dominant Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE, EARLY ONSET

Contacts and locations

Locations

Clinical Site(s)
RECRUITING

's-Hertogenbosch, Netherlands
Clinical Site(s)
RECRUITING

Amsterdam, Netherlands
Clinical Site(s)
RECRUITING

Zwolle, Netherlands
Clinical Site(s)
RECRUITING

London, United Kingdom

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