New hope for lymphoma patients too frail for standard chemo

NCT ID NCT01679119

Completed Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

Summary

This trial tested two different drug combinations for patients with an aggressive type of blood cancer called DLBCL, who could not receive the standard chemotherapy due to heart risks or older age. It directly compared adding a newer targeted drug (inotuzumab ozogamicin) to a standard regimen versus adding an older chemotherapy drug (gemcitabine). The goal was to find a safer, effective first treatment for this vulnerable group, measuring how long patients lived without their cancer getting worse and their quality of life.

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Contacts and locations

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Locations

Aintree University Hospital

Liverpool, United Kingdom
Beatson West of Scotland Cancer Centre (including Gartnavel Royal Hospital)

Glasgow, United Kingdom
Bristol Oncology Centre

Bristol, United Kingdom
Castle Hill Hospital

Cottingham, United Kingdom
Christie Hospital

Manchester, United Kingdom
Churchill Hospital

Oxford, United Kingdom
Darent Valley Hospital

Dartford, United Kingdom
Derriford Hospital

Plymouth, United Kingdom
Freeman Hospital

Newcastle, United Kingdom
Guy's Hospital (including St Thomas's Hospital)

London, United Kingdom
James Paget University Hospital

Great Yarmouth, United Kingdom
Kent and Canterbury Hospital

Canterbury, United Kingdom
Kettering General Hospital

Kettering, United Kingdom
Kings Mill Hospital

Sutton in Ashfield, United Kingdom
Leicester Royal Infirmary

Leicester, United Kingdom
Luton and Dunstable Hospital

Luton, United Kingdom
Medway Maritime Hospital

Gillingham, United Kingdom
Norfolk and Norwich University Hospital

Norwich, United Kingdom
North Hampshire Hospital

Basingstoke, United Kingdom
North Tyneside Hosptial (including Wansbeck Hospital and Hexham General Hospital)

North Shields, United Kingdom
Northwick Park Hospital

Harrow, United Kingdom
Nottingham City Hospital

Nottingham, United Kingdom
Princess Royal University Hospital

Orpington, United Kingdom
Queen's Hospital

Romford, United Kingdom
Royal Bournemouth Hospital

Bournemouth, United Kingdom
Royal Cornwall Hospital

Truro, United Kingdom
Royal Devon & Exeter Hospital

Exeter, United Kingdom
Royal Free Hospital

London, United Kingdom
Royal Hampshire County Hospital

Winchester, United Kingdom
Royal Liverpool University Hospital

Liverpool, United Kingdom
Royal United Hospital

Bath, United Kingdom
Southampton General Hospital

Southampton, United Kingdom
St James's University Hospital

Leeds, United Kingdom
Stoke Mandeville Hospital (including Wycombe Hospital)

Aylesbury, United Kingdom
Torbay Hospital

Torquay, United Kingdom
University College London Hospital

London, United Kingdom
University Hospital, Coventry

Coventry, United Kingdom
West Suffolk Hospital

Bury St Edmunds, United Kingdom
Worcester Royal Hospital (including Kidderminster Hospital and Alexandra Hospital)

Worcester, United Kingdom
Wythenshawe Hospital (including Trafford General Hospital)

Wythenshawe, United Kingdom

Conditions

Explore the condition pages connected to this study.

DIFFUSE LARGE B-CELL LYMPHOMA