New drug aims to reduce Blood-Letting in rare blood cancer

NCT ID NCT06985147

Ongoing Disease control Sponsor: Disc Medicine, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study tests an experimental drug called DISC-3405 in 60 adults with polycythemia vera, a condition where the body makes too many red blood cells. The goal is to see if the drug can safely lower the need for phlebotomies (blood removal) and control blood counts. Participants will receive increasing doses of the drug and be monitored for side effects and effectiveness.

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Conditions

The condition(s) this trial relates to.

acquired polycythemia vera

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POLYCYTHEMIA VERA (PV)

Contacts and locations

Locations

Atrium Health - Levine Cancer Center

Charlotte, North Carolina, 28204, United States
Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Duke University

Durham, North Carolina, 27705, United States
Keck Medicine of USC - Cancer Clinic- Newport Beach

Newport Beach, California, 92663, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Mayo Clinic in Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic in Minnesota

Rochester, Minnesota, 55905, United States
Ohio State University

Columbus, Ohio, 43210, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Siteman Cancer Center - Washington University St. Louis

St Louis, Missouri, 63110, United States
UCLA Health

Los Angeles, California, 90095, United States
USC Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University of Washington - Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.