Sound waves open brain barrier to attack deadly childhood tumor

NCT ID NCT05630209

First seen Nov 01, 2025 · Last updated Jun 14, 2026 · Updated 24 times

Summary

This study tests whether using focused ultrasound to temporarily open the blood-brain barrier can safely deliver the chemotherapy drug doxorubicin to treat a rare and aggressive brain tumor called DIPG in children and young adults. Ten participants aged 5 to 21 will receive the treatment and be monitored for side effects and how well the drug reaches the tumor. The goal is to find a safer, more effective way to treat this difficult cancer.

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Contacts and locations

Locations

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • Cook Children's Health Care System

    Fort Worth, Texas, 76104, United States

  • Nicklaus Children's Hospital

    Miami, Florida, 33155, United States

Conditions

Explore the condition pages connected to this study.