Cure My Disease

Don't miss your cure!

 Log in / Sign up

Chest wrinkle treatment shows promise in new study

NCT ID NCT05163353

Symptom relief Sponsor: Merz North America, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether diluted Radiesse injections can safely reduce wrinkles on the décolleté (upper chest). 152 women aged 30 to 65 received the treatment. At 24 weeks, more than half showed at least a one-point improvement on a wrinkle severity scale.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
diluted Radiesse (calcium hydroxylapatite)
What this could lead to
If successful, this could offer a safe, effective option for reducing wrinkles on the upper chest area.
What could go wrong
This is a cosmetic treatment, not a cure for any disease. Results may vary, and risks include injection-related side effects like swelling or bruising.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

152 people

The number who actually took part.

Started

Dec 2021

Finished

Jun 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female between ≥ 30 and ≤ 65 years old at the time of the screening. * Subjects seeking improvement of décolleté wrinkles. Exclusion Criteria: * Any previous surgery, including plastic surgery or permanent surgical implant in the treatment area. * Previous treatment with collagen fillers, calcium hydroxylapatite, and/or long-lasting hyaluronic acid (HA) fillers in the décolleté, or with other HA fillers in the décolleté. * Previous treatment with botulinum toxin, ablative or fractional laser, microdermabrasion, microneedling, chemical peels, and/or non-invasive skin tightening in the décolleté.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Décolleté wrinkles are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Décolleté wrinkles

Contacts and locations

Locations

  • Clinical Testing of Beverly Hills, Merz Investigational Site #0010395

    Beverly Hills, California, 90210, United States

  • Cosmetic Laser Dermatology, Merz Investigational Site #0010321

    San Diego, California, 92121, United States

  • Face Beautiful Inc, Merz Investigational Site #0010358

    Vista, California, 92083, United States

  • Facial Plastic Surgery, Merz Investigational Site #0010463

    Redondo Beach, California, 90277, United States

  • Nashville Center for Laser and Facial Surgery, Merz Investigational Site #0010353

    Nashville, Tennessee, 37203, United States

  • Private Practice, Merz Investigational Site #0010299

    Santa Monica, California, 90404, United States

  • Research Institute of the Southeast, LLC, Merz Investigational Site #0010420

    West Palm Beach, Florida, 33401, United States

  • Skin Associates of South Florida, Merz Investigational Site #0010101

    Coral Gables, Florida, 33146, United States

  • The Graivier Center, Merz Investigational Site #0010464

    Alpharetta, Georgia, 30005, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.