New depression combo shows promise in Head-to-Head trial

NCT ID NCT06957223

First seen May 14, 2026 ยท Last updated May 14, 2026

Summary

This study tested whether a combination of two drugs (dextromethorphan and bupropion) works better than standard antidepressants (SSRIs) for adults with major depression. 80 participants were randomly assigned to one of the two treatments for 6 weeks. The goal was to see if the new combo could improve depression symptoms and lead to remission more effectively.

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Contacts and locations

Locations

  • Combined Military Hospital

    Nowshera, KPK, 25770, Pakistan

  • Department of Psychiatry, Combined Military Hospital Nowshera

    Nowshera, KPK, 25770, Pakistan

Conditions

Explore the condition pages connected to this study.