New hope for stomach cancer: drug combo shows promise in shrinking tumors

NCT ID NCT04379596

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 08, 2026 · Updated 23 times

Summary

This study is for people with advanced HER2-positive stomach or esophageal cancer. It tests a drug called trastuzumab deruxtecan (T-DXd) alone or with chemotherapy and/or immunotherapy to see if it can shrink tumors and be safe. About 450 adults will take part. The goal is to control the disease, not cure it.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Research Site
WITHDRAWN

Santa Monica, California, 90404, United States
Research Site
WITHDRAWN

Westwood, Kansas, 66205, United States
Research Site
RECRUITING

Baltimore, Maryland, 21287, United States
Research Site
WITHDRAWN

Boston, Massachusetts, 02114, United States
Research Site
RECRUITING

Boston, Massachusetts, 02215, United States
Research Site
WITHDRAWN

Ann Arbor, Michigan, 48109, United States
Research Site
RECRUITING

New York, New York, 10065, United States
Research Site
WITHDRAWN

Durham, North Carolina, 27710, United States
Research Site
RECRUITING

Houston, Texas, 77090, United States
Research Site
WITHDRAWN

Fairfax, Virginia, 22031, United States
Research Site
WITHDRAWN

Florianópolis, 88020-210, Brazil
Research Site
COMPLETED

Londrina, 86015-520, Brazil
Research Site
WITHDRAWN

Natal, 59075-740, Brazil
Research Site
WITHDRAWN

Porto Alegre, 90160-093, Brazil
Research Site
ACTIVE_NOT_RECRUITING

Ribeirão Preto, 14051-140, Brazil
Research Site
WITHDRAWN

Rio de Janeiro, 22793-080, Brazil
Research Site
RECRUITING

Santa Maria, 97015-450, Brazil
Research Site
RECRUITING

São Jose Do Rio Preto, 15090-000, Brazil
Research Site
WITHDRAWN

São Paulo, 01509-900, Brazil
Research Site
WITHDRAWN

São Paulo, 03102-002, Brazil
Research Site
ACTIVE_NOT_RECRUITING

São Paulo, 045202-001, Brazil
Research Site
WITHDRAWN

Edmonton, Alberta, T6G 1Z2, Canada
Research Site
WITHDRAWN

Ottawa, Ontario, K1H 8L6, Canada
Research Site
WITHDRAWN

Toronto, Ontario, M4N 3M5, Canada
Research Site
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Research Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Research Site
RECRUITING

Québec, Quebec, G1J 1Z4, Canada
Research Site
RECRUITING

Chengdu, 610042, China
Research Site
RECRUITING

Guangzhou, 510062, China
Research Site
WITHDRAWN

Guiyang, 550002, China
Research Site
WITHDRAWN

Hangzhou, 310022, China
Research Site
RECRUITING

Hefei, 230001, China
Research Site
WITHDRAWN

Hefei, 230601, China
Research Site
RECRUITING

Shanghai, 200025, China
Research Site
WITHDRAWN

Shanghai, 200031, China
Research Site
RECRUITING

Shanghai, 200032, China
Research Site
WITHDRAWN

Shanghai, 200050, China
Research Site
RECRUITING

Shenyang, 110001, China
Research Site
WITHDRAWN

Ürümqi, 830000, China
Research Site
RECRUITING

Wuhan, 430000, China
Research Site
WITHDRAWN

Xiamen, 361003, China
Research Site
RECRUITING

Zhengzhou, 450008, China
Research Site
RECRUITING

Frankfurt, 60488, Germany
Research Site
RECRUITING

Frankfurt, 60590, Germany
Research Site
RECRUITING

Hamburg, 20249, Germany
Research Site
RECRUITING

Leipzig, 04103, Germany
Research Site
RECRUITING

Mannheim, 68167, Germany
Research Site
RECRUITING

München, 81675, Germany
Research Site
RECRUITING

Milan, 20133, Italy
Research Site
RECRUITING

Milan, 20162, Italy
Research Site
RECRUITING

Naples, 80131, Italy
Research Site
RECRUITING

Padova, 35128, Italy
Research Site
RECRUITING

Roma, 00168, Italy
Research Site
RECRUITING

Verona, 37134, Italy
Research Site
RECRUITING

Chūōku, 104-0045, Japan
Research Site
RECRUITING

Kashiwa, 277-8577, Japan
Research Site
RECRUITING

Kita-gun, 761-0793, Japan
Research Site
RECRUITING

Ota-shi, 373-8550, Japan
Research Site
RECRUITING

Amsterdam, 1066CX, Netherlands
Research Site
RECRUITING

Amsterdam, 1081 HV, Netherlands
Research Site
RECRUITING

Utrecht, 3584CG, Netherlands
Research Site
RECRUITING

Gdansk, 80-214, Poland
Research Site
RECRUITING

Konin, 62-500, Poland
Research Site
RECRUITING

Koszalin, 75-581, Poland
Research Site
RECRUITING

Krakow, 31-501, Poland
Research Site
WITHDRAWN

Lublin, 20-090, Poland
Research Site
WITHDRAWN

Opole, 45-061, Poland
Research Site
WITHDRAWN

Tomaszów Mazowiecki, 97-200, Poland
Research Site
RECRUITING

Warsaw, 02-034, Poland
Research Site
SUSPENDED

Kostroma, 156005, Russia
Research Site
SUSPENDED

Moscow, 115478, Russia
Research Site
TERMINATED

Moscow, 125284, Russia
Research Site
SUSPENDED

Moscow, 143423, Russia
Research Site
TERMINATED

Moscow, 143442, Russia
Research Site
SUSPENDED

Novosibirsk, 630099, Russia
Research Site
COMPLETED

Saint Petersburg, 195271, Russia
Research Site
SUSPENDED

Saint Petersburg, 196603, Russia
Research Site
SUSPENDED

Saint Petersburg, 197022, Russia
Research Site
COMPLETED

Saint Petersburg, 197758, Russia
Research Site
RECRUITING

Seongnam-si, 13620, South Korea
Research Site
RECRUITING

Seoul, 03080, South Korea
Research Site
RECRUITING

Seoul, 03722, South Korea
Research Site
RECRUITING

Seoul, 05505, South Korea
Research Site
RECRUITING

Seoul, 06351, South Korea
Research Site
RECRUITING

Barcelona, 08035, Spain
Research Site
RECRUITING

Madrid, 28007, Spain
Research Site
RECRUITING

Madrid, 28034, Spain
Research Site
RECRUITING

Santander, 39008, Spain
Research Site
RECRUITING

Seville, 41013, Spain
Research Site
RECRUITING

Kaohsiung City, 80756, Taiwan
Research Site
WITHDRAWN

Kaohsiung City, 83301, Taiwan
Research Site
RECRUITING

Tainan, 704, Taiwan
Research Site
RECRUITING

Taipei, 10002, Taiwan
Research Site
RECRUITING

Taipei, 11217, Taiwan
Research Site
RECRUITING

Taoyuan, 333, Taiwan
Research Site
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Research Site
RECRUITING

Dundee, DD1 9SY, United Kingdom
Research Site
RECRUITING

London, NW1 2PG, United Kingdom
Research Site
RECRUITING

Manchester, M20 4BX, United Kingdom
Research Site
RECRUITING

Sutton, SM2 5PT, United Kingdom

Conditions

Explore the condition pages connected to this study.

GASTRIC CANCER