New shot shrinks nasal polyps in major trial

NCT ID NCT05274750

Completed Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jan 11, 2026 · Last updated May 12, 2026 · Updated 22 times

Summary

This study tested a monthly injection called depemokimab in 276 adults with chronic sinusitis and nasal polyps. The goal was to see if it could shrink polyps and ease nasal blockage over 52 weeks. Results showed improvement in polyp size and nasal obstruction scores compared to placebo.

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Contacts and locations

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Locations

GSK Investigational Site

Tucson, Arizona, 85704, United States
GSK Investigational Site

Buena Park, California, 90621, United States
GSK Investigational Site

Los Angeles, California, 90006, United States
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San Diego, California, 91942, United States
GSK Investigational Site

Stanford, California, 94304, United States
GSK Investigational Site

Temecula, California, 92592, United States
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Aurora, Colorado, 80045, United States
GSK Investigational Site

Gainesville, Florida, 32605, United States
GSK Investigational Site

Tamarac, Florida, 33321, United States
GSK Investigational Site

Tampa, Florida, 33613, United States
GSK Investigational Site

Meridian, Idaho, 83642, United States
GSK Investigational Site

Meridian, Idaho, 83706, United States
GSK Investigational Site

Chicago, Illinois, 60612, United States
GSK Investigational Site

Lexington, Kentucky, 40509, United States
GSK Investigational Site

Louisville, Kentucky, 40205, United States
GSK Investigational Site

Boston, Massachusetts, 02135, United States
GSK Investigational Site

New Brunswick, New Jersey, 08901, United States
GSK Investigational Site

Great Neck, New York, 11021, United States
GSK Investigational Site

Rochester, New York, 14642, United States
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Chapel Hill, North Carolina, 27599, United States
GSK Investigational Site

Cincinnati, Ohio, 45267, United States
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Tulsa, Oklahoma, 74137, United States
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Bethlehem, Pennsylvania, 18017, United States
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Providence, Rhode Island, 02914, United States
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Dallas, Texas, 75390-9035, United States
GSK Investigational Site

Richmond, Virginia, 23235, United States
GSK Investigational Site

Buenos Aires, 1023, Argentina
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Buenos Aires, C1425BEN, Argentina
GSK Investigational Site

Buenos Aires, C1426ABP, Argentina
GSK Investigational Site

Ciudad Autonoma de Bueno, C1121ABE, Argentina
GSK Investigational Site

Florida, B1602DOH, Argentina
GSK Investigational Site

La Plata, 1900, Argentina
GSK Investigational Site

Mar del Plata, 7600, Argentina
GSK Investigational Site

Mendoza, 5500, Argentina
GSK Investigational Site

Mendoza, M5500CCG, Argentina
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Rosario, S2000DBS, Argentina
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Ghent, 9000, Belgium
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Hamilton, Ontario, L8L 2X2, Canada
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London, Ontario, N6A 4V2, Canada
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Ottawa, Ontario, K1H 1E4, Canada
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Montreal, Quebec, H2V 2K1, Canada
GSK Investigational Site

Montreal, Quebec, H2X 3E4, Canada
GSK Investigational Site

Québec, Quebec, G1S 4L8, Canada
GSK Investigational Site

Québec, Quebec, G1V 4W2, Canada
GSK Investigational Site

Beijing, 100191, China
GSK Investigational Site

Beijing, 100730, China
GSK Investigational Site

Dongguan, 523326, China
GSK Investigational Site

Jingzhou, 434020, China
GSK Investigational Site

Nanchang, 330006, China
GSK Investigational Site

Qingdao, 266061, China
GSK Investigational Site

Shanghai, 200065, China
GSK Investigational Site

Taiyuan, 300201, China
GSK Investigational Site

Wenzhou, 325000, China
GSK Investigational Site

Wuhan, 430022, China
GSK Investigational Site

Yantai, 264000, China
GSK Investigational Site

Clermont-Ferrand, 63003, France
GSK Investigational Site

Créteil, 94010, France
GSK Investigational Site

Grenoble, 38043, France
GSK Investigational Site

La Roche-sur-Yon, 85925, France
GSK Investigational Site

La Rochelle, 17019, France
GSK Investigational Site

Marseille, 13005, France
GSK Investigational Site

Montpellier, 34295, France
GSK Investigational Site

Nantes, 44093, France
GSK Investigational Site

Pontoise, 95300, France
GSK Investigational Site

Toulouse, 31059, France
GSK Investigational Site

Valenciennes, 59322, France
GSK Investigational Site

Bonn, 53127, Germany
GSK Investigational Site

Dortmund, 44137, Germany
GSK Investigational Site

Dresden, 01139, Germany
GSK Investigational Site

Dresden, 01307, Germany
GSK Investigational Site

Düsseldorf, 40225, Germany
GSK Investigational Site

Düsseldorf, 40549, Germany
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Marburg, 35043, Germany
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München, 81377, Germany
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Münster, 48149, Germany
GSK Investigational Site

Wiesbaden, 65183, Germany
GSK Investigational Site

Ehime, 790-0024, Japan
GSK Investigational Site

Ehime, 798-8510, Japan
GSK Investigational Site

Fukui, 910-1193, Japan
GSK Investigational Site

Fukuoka, 806-8501, Japan
GSK Investigational Site

Ishikawa, 920-0293, Japan
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Kanagawa, 231-8682, Japan
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Kanagawa, 250-8558, Japan
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Kumamoto, 860-0814, Japan
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Kyoto, 600-8216, Japan
GSK Investigational Site

Mie, 514-8507, Japan
GSK Investigational Site

Nagano, 392-8510, Japan
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Osaka, 560-0082, Japan
GSK Investigational Site

Osaka, 570-8507, Japan
GSK Investigational Site

Tokyo, 160-0023, Japan
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Tokyo, 173-0026, Japan
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Amsterdam, 1105 AZ, Netherlands
GSK Investigational Site

Leiden, 2353 GA, Netherlands
GSK Investigational Site

Barcelona, 08022, Spain
GSK Investigational Site

Barcelona, 08036, Spain
GSK Investigational Site

Jerez de la Frontera, 11407, Spain
GSK Investigational Site

Madrid, 28034, Spain
GSK Investigational Site

Madrid, 28040, Spain
GSK Investigational Site

Pamplona, 31008, Spain
GSK Investigational Site

Seville, 41009, Spain
GSK Investigational Site

Valladolid, 47005, Spain
GSK Investigational Site

Zaragoza, 50009, Spain
GSK Investigational Site

Great Yarmouth, NR31 6LA, United Kingdom
GSK Investigational Site

Stevenage, SG1 4AB, United Kingdom
GSK Investigational Site

Wigan, WN1 2NN, United Kingdom

Conditions

Explore the condition pages connected to this study.

NASAL POLYPS