Scientists test how past dengue infections affect new vaccine response

This early-stage study is testing a potential new dengue vaccine in healthy adults to see if it's safe and how people's immune systems respond differently based on whether they've had dengue before. Researchers are enrolling 127 participants aged 18-59 who have never had dengue, had it once, or had it multiple times. The main goal is to understand how prior dengue exposure affects vaccine safety and immune response, not to prove the vaccine prevents disease.