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Could daylight hold the key to preventing delirium?

NCT ID NCT07791472

Knowledge-focused Sponsor: King's College Hospital NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This pilot study investigates whether changes in the body clock, influenced by light exposure, are linked to delirium in critical care patients. Researchers will measure light levels at the bedside, collect blood samples to check for body clock markers and proteins related to delirium, and assess participants for confusion. After leaving critical care, participants will take memory and thinking tests. The goal is to understand why lack of daylight is a risk factor for delirium and to identify potential treatment targets.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Light exposure management and blood biomarker analysis
What this could lead to
If this pilot succeeds, it could point toward new ways to prevent delirium and reduce memory and thinking problems after critical illness.
What could go wrong
This is a small pilot study with only 10 participants, so findings may not apply broadly. It aims to test feasibility, not to prove that light interventions work.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients in critical care

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients \>50 years old * Patients admitted to critical care in previous 24 hours * Patients with an arterial or venous access line suitable for blood sampling * Patients with an expected length of stay \>36 hours Exclusion Criteria: * Patients with a primary neurosurgical diagnosis * Patients with pre-existing cognitive impairment * Patients expected to die within 24 hours or receiving end of life treatment

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Conditions

The condition(s) this trial relates to.

delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Circadian rhythm disruption Delirium

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • King's College Hospital NHS Foundation Trust

    RECRUITING

    London, United Kingdom

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