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Vacuum dressing may cut infection in dirty surgical wounds

NCT ID NCT04042259

Disease control Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This trial investigates whether using a negative pressure wound therapy device (a vacuum dressing) for delayed primary closure can reduce wound infections and other complications in patients with contaminated or dirty abdominal wounds. Participants are adults who have had an open abdomen after surgery and are at high risk for infection. The study compares outcomes to a historical group that did not receive the device.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Negative pressure wound therapy device (Abthera, VERAFLO, Prevena)
What this could lead to
If successful, this approach could lower infection rates and shorten healing time for patients with dirty abdominal wounds after surgery.
What could go wrong
This is a small, single-center study with no control group, and earlier research has shown mixed results. The therapy may not reduce complications and could increase costs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Aug 2020

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years or older * undergone midline laparotomy and managed with an open abdomen for at least one day * contaminated or dirty wound classification Exclusion Criteria: * Less than 18 years of age * Prisoners * Pregnant females * Non-surgical patients

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Conditions

The condition(s) this trial relates to.

Intraabdominal Infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infection abdominal

Contacts and locations

Locations

  • Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States