New catheter lock aims to stop deadly infections in home nutrition patients
NCT ID NCT06822426
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether a catheter lock solution called DefenCath can prevent central line-associated bloodstream infections (CLABSIs) in adults who receive total parenteral nutrition (TPN) at home through a central line. About 200 participants will be randomly assigned to receive either DefenCath or a standard heparin lock. The study will compare how many people in each group develop an infection within 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
taurolidine and heparin catheter lock solution
What this could lead to
If successful, this could provide a new way to prevent dangerous bloodstream infections in people who need long-term nutrition through a central line.
What could go wrong
This is a mid-stage trial with 200 participants, so results may not apply to everyone. The treatment involves a catheter lock solution, which carries risks like bleeding or allergic reactions.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Alchemi - Sugarland
RECRUITINGSugar Land, Texas, 77478, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ankara Bilkent City Hospital
NOT_YET_RECRUITINGÇankaya, Ankara, 06800, Turkey (Türkiye)
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ankara University Ibni Sina Research and Application Hospital
NOT_YET_RECRUITINGÇankaya, Ankara, 06230, Turkey (Türkiye)
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Bioresearch Partner
RECRUITINGDoral, Florida, 33122, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke University Hospital
WITHDRAWNDurham, North Carolina, 27710, United States
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Emory University Hospital - GCRC
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Hacettepe University Hospitals
NOT_YET_RECRUITINGAltındağ, Ankara, 06230, Turkey (Türkiye)
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hacettepe University Hospitals
NOT_YET_RECRUITINGYenimahalle, Ankara, 06560, Turkey (Türkiye)
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Istanbul University Faculty of Medicine, Capa State Hospital
NOT_YET_RECRUITINGIstanbul, 34093, Turkey (Türkiye)
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Johns Hopkins Clinical Research Unit
RECRUITINGBaltimore, Maryland, 21205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MedStar Health Research Institute
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mount Sinai Medical Center
RECRUITINGNew York, New York, 10029, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California Los Angeles
RECRUITINGLos Angeles, California, 90024, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Iowa Health Care
RECRUITINGIowa City, Iowa, 52242, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198-3285, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt Center for Human Nutrition
RECRUITINGNashville, Tennessee, 37212-1150, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••