New catheter lock aims to stop deadly infections in home nutrition patients
NCT ID NCT06822426
First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 5 times
Summary
This phase 3 trial tests whether a catheter lock solution called DefenCath can prevent central line-associated bloodstream infections (CLABSIs) in adults who receive total parenteral nutrition (TPN) at home through a central line. About 200 participants will be randomly assigned to receive either DefenCath or a standard heparin lock. The study will compare how many people in each group develop an infection within 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- taurolidine and heparin catheter lock solution
- What this could lead to
- If successful, this could provide a new way to prevent dangerous bloodstream infections in people who need long-term nutrition through a central line.
- What could go wrong
- This is a mid-stage trial with 200 participants, so results may not apply to everyone. The treatment involves a catheter lock solution, which carries risks like bleeding or allergic reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alchemi - Sugarland
RECRUITINGSugarland, Texas, 77478, United States
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Ankara Bilkent City Hospital
RECRUITINGÇankaya, Ankara, 06800, Turkey (Türkiye)
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Ankara University Ibni Sina Research and Application Hospital
RECRUITINGÇankaya, Ankara, 06230, Turkey (Türkiye)
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Bioresearch Partner
RECRUITINGDoral, Florida, 33122, United States
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Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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Duke University Hospital
WITHDRAWNDurham, North Carolina, 27710, United States
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Emory University Hospital - GCRC
RECRUITINGAtlanta, Georgia, 30322, United States
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Hacettepe University Hospitals
RECRUITINGAltındağ, Ankara, 06230, Turkey (Türkiye)
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Hacettepe University Hospitals
RECRUITINGYenimahalle, Ankara, 06560, Turkey (Türkiye)
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Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Istanbul University Faculty of Medicine, Capa State Hospital
RECRUITINGIstanbul, Istanbul, 34093, Turkey (Türkiye)
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Johns Hopkins Clinical Research Unit
RECRUITINGBaltimore, Maryland, 21205, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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MedStar Health Research Institute
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Email: •••••@•••••
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Mount Sinai Medical Center
RECRUITINGNew York, New York, 10029, United States
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Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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University of California Los Angeles
RECRUITINGLos Angeles, California, 90024, United States
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University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
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University of Iowa Health Care
RECRUITINGIowa City, Iowa, 52242, United States
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198-3285, United States
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Vanderbilt Center for Human Nutrition
RECRUITINGNashville, Tennessee, 37212-1150, United States
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