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Zapping deep brain regions without surgery to restore leg movement after stroke

NCT ID NCT07833423

Symptom relief Sponsor: The Third People's Hospital of Huizhou Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 22, 2026 · Last updated Sep 23, 2026 · Updated 1 time

Summary

Researchers are testing a non-invasive brain stimulation technique called temporal interference (TI) to see if it can help stroke survivors regain lower limb movement. The trial enrolls 60 adults who had their first stroke one to six months earlier and have leg weakness. Participants receive TI stimulation aimed at the striatum, a deep brain region, along with standard rehabilitation training. The main goal is to measure changes in leg motor function using a standard stroke scale.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-invasive temporal interference brain stimulation targeting the striatum
What this could lead to
If it works, this could offer a non-surgical way to reach deep brain regions and help stroke survivors regain leg movement.
What could go wrong
The trial is small and early, so results may not hold up in larger groups. The stimulation may cause scalp discomfort or headaches, and some participants may not improve.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The patients met the diagnostic criteria of stroke formulated by the Fourth National Cerebrovascular Disease Conference and were confirmed by head CT or MRI. * The duration of the first episode ranged from 1 to 6 months. * Age ranged from 18 to 75 years and both sexes were included. * There was definite lower limb dysfunction, and Brunnstrom stage of lower limbs was II-IV. * Informed consent was obtained voluntarily. Exclusion Criteria: * People with metallic implants (e.g., aneurysm clips, pacemakers) or skull defects. * Have a history of epilepsy or are taking medications that may lower the seizure threshold. * Patients with severe heart, liver, kidney dysfunction or other serious physical diseases. * Pregnant or lactating women. * Patients with skin allergy or skin lesions at irritating sites. * Hemorrhagic lesions in the basal ganglia (including previous or current basal ganglia hemorrhage). * Impairment of lower limb mobility due to other nonstroke factors was sufficient to significantly affect the primary outcome assessor. * Inability to cooperate with investigators. * At the same time, he participated in other research projects.

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

How to take part

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  1. The official record

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