New Dual-Targeting CAR t therapy shows promise for Tough-to-Treat lymphoma

NCT ID NCT04697940

First seen Nov 01, 2025 · Last updated May 02, 2026 · Updated 17 times

Summary

This study tests a new treatment for people with B-cell Non-Hodgkin's lymphoma that has come back or stopped responding to standard therapy. The treatment uses a patient's own immune cells that are modified to target two proteins (CD19 and CD20) on cancer cells, plus a drug called decitabine to make the cells work better. The goal is to see if this approach is safe and effective, with up to 33 participants in two phases.

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Contacts and locations

Locations

  • Biotherapeutic Department of Chinese PLA General Hospital

    Beijing, Beijing Municipality, 100853, China

Conditions

Explore the condition pages connected to this study.