New pill combo targets tough cancers in early trial

NCT ID NCT03968653

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 35 times

Summary

This early-phase study tested an oral drug called Debio 0123 combined with the chemotherapy carboplatin in 76 adults with advanced solid tumors that had come back or worsened after prior platinum-based treatment. The main goals were to find the safest dose and check for side effects. The study was terminated early, so results are limited.

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Contacts and locations

Locations

  • Clinica Universidad de Navarra

    Madrid, 28027, Spain

  • Clinica Universidad de Navarra - Pamplona

    Pamplona, 31008, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital Vall Hebrón, Unidad de Investigación en Terapia Molecular (UITM)

    Barcelona, 08035, Spain

  • Instituto Valenciano de Oncologia

    Valencia, 46009, Spain

  • Leiden University Medical Center, Dept. of Clinical Oncology

    Leiden, 2333, Netherlands

  • Radboud university medical center

    Nijmegen, 6525, Netherlands

  • University Medical Center Groningen

    Groningen, 9713, Netherlands

Conditions

Explore the condition pages connected to this study.