New combo therapy targets hard-to-treat GIST tumors
NCT ID NCT05957367
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 4 times
Summary
This study tests a new drug called DCC-3116 combined with other cancer treatments for people with advanced GIST, a type of stomach or intestinal cancer. The goal is to find safe doses and see if the combination shrinks tumors. About 94 adults whose cancer has worsened after standard treatment can join.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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AOU Careggi - Padiglione 16 - Piano Terra - Ambulatori Oncologici - Ufficio Trial
RECRUITINGFlorence, 50134, Italy
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Aarhus University Hospital
RECRUITINGAarhus, 8200, Denmark
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Antonie Van Leeuwenhoek Hospital
RECRUITINGAmsterdam, 1066 CX, Netherlands
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Centre Oscar Lambret
RECRUITINGLille, 59020, France
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Cleveland Clinic Taussig Cancer Center
RECRUITINGCleveland, Ohio, 44195, United States
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Fox Chase Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19111, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Clinico San Carlos
RECRUITINGMadrid, 28040, Spain
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, 28034, Spain
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Hospital Universitario Virgen Del Rocio
RECRUITINGSeville, 41013, Spain
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Hôpital Européen Georges Pompidou
RECRUITINGParis, 75015, France
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ICO Hospitalet
RECRUITINGBarcelona, 08908, Spain
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IRCCS Azienda Ospedaliera Metropolitana
RECRUITINGGenova, 16132, Italy
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Inselspital Universitätsklinikum Bern
RECRUITINGBern, 3010, Switzerland
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Institut Curie, Service d'Oncologie Médicale
RECRUITINGParis, 75005, France
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Instituto Português de Oncologia do Porto Francisco Gentil, E.P.E.
RECRUITINGPorto, 4200-072, Portugal
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Istituto Europeo di Oncologia
RECRUITINGMilan, 20141, Italy
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Memorial Sloan Kettering Cancer Center - Main Campus
RECRUITINGNew York, New York, 10065, United States
Contact Email: •••••@•••••
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Contact Email: •••••@•••••
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Radboudumc
RECRUITINGNijmegen, 6525GA, Netherlands
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START Midwest
RECRUITINGGrand Rapids, Michigan, 49546, United States
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Sylvester Comprehensive Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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UCLA Department of Medicine-Hematology/Oncology
RECRUITINGLos Angeles, California, 90095, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitatsklinikum Franfurt
RECRUITINGFrankfurt, 60590, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Massachusetts Worcester
RECRUITINGWorcester, Massachusetts, 01655, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Southern California - Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Eppendorf
RECRUITINGHamburg, 20246, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Cancer Specialist, PC
RECRUITINGFairfax, Virginia, 22031, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University School of Medicine - Siteman Cancer Center
RECRUITINGSt Louis, Missouri, 63110, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a targeted pill shrink a rare, Treatment-Resistant stomach cancer?
- Massive GIST registry aims to unlock secrets of rare cancer
- New hope for stomach cancer patients Who've tried everything?
- New hope for GIST: experimental combo targets hard-to-treat tumors
- New study seeks best way to remove stomach tumors without major surgery
- Hunt for hidden cancer genes: families needed to unlock hereditary secrets