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Could Right-Sided brain stimulation unlock the mystery of freezing gait?

NCT ID NCT06994728

Knowledge-focused Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This study explores how deep brain stimulation (DBS) on the right versus left side of the brain affects attention and freezing of gait in people with Parkinson's disease. Freezing of gait is a sudden inability to move forward, and there is no reliable treatment. Researchers will temporarily turn off each side of the DBS in 12 participants to see if right-sided stimulation improves visual attention and reduces freezing episodes. The goal is to understand the brain mechanisms behind this disabling symptom and potentially guide better DBS settings.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Deep brain stimulation (DBS) with each side of the subthalamic nucleus turned off sequentially
What this could lead to
If right-sided stimulation improves attention and reduces freezing of gait, it could guide more personalized DBS settings for Parkinson's patients.
What could go wrong
This is a small, early study with only 12 participants, so results may not apply broadly. Turning off one side of DBS temporarily could worsen symptoms during testing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects above 18 years of age * Subjects with freezing of gait * Subjects with bilateral STN-DBS surgery as part of their clinical care for Parkinson's disease Exclusion Criteria: * Uncorrected visual or hearing impairments, as indicated by self-report * Individuals who are pregnant or expect to become pregnant during the course of the study * Individuals with dementia or relevant brain lesions impacting cognition or gait

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Conditions

The condition(s) this trial relates to.

Gait Disorders, Neurologic Parkinson disease spatial visualization, aptitude for

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gait disorders, neurologic Parkinson disease Visuospatial/perceptual abilities

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29403, United States

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