New combo offers hope for melanoma patients who failed standard therapy
NCT ID NCT04971499
First seen Feb 22, 2026 · Last updated May 13, 2026 · Updated 15 times
Summary
This study tests a combination of two drugs, dapansutrile and pembrolizumab, in people with advanced melanoma that no longer responds to PD-1 inhibitors. The trial has two parts: first, finding a safe dose of dapansutrile with pembrolizumab, and second, checking if the combo shrinks tumors. About 26 adults with stage 3 or 4 melanoma that cannot be surgically removed are participating.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Duke Cancer Center
Durham, North Carolina, 27710, United States
Conditions
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