New drug combo aims to shrink Hard-to-Treat breast tumors before surgery

NCT ID NCT07618923

First seen Jun 02, 2026 · Last updated Jun 16, 2026 · Updated 2 times

Summary

This study tests a two-step treatment for people with a common type of breast cancer (HR+/HER2-low) that has a higher risk of coming back. First, patients take a daily pill (dalpiciclib) plus a hormone blocker for about 4 months, then receive an IV drug (SHR-A1811) every 3 weeks for another 3 months. The goal is to shrink tumors before surgery, and researchers will check how many patients have a complete or partial response. About 20 adults with stage II or III breast cancer will take part.

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