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New surgical implant fights infection for a month

NCT ID NCT04233424

Completed Prevention Sponsor: PolyPid Ltd. Source: ClinicalTrials.gov ↗

Summary

This large, completed Phase 3 trial tested whether a new antibiotic implant called D-PLEX could prevent wound infections after major abdominal surgery. The implant, placed during surgery, slowly releases an antibiotic at the incision site for about 30 days. Nearly 1,000 patients undergoing elective colon surgery were randomly assigned to receive the implant plus standard care or standard care alone to see which group had fewer infections.

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Contacts and locations

Locations

  • "IV Multiprofile Hospital for Active Treatment - Sofia" EAD

    Sofia, 1606, Bulgaria

  • "MHAT Sveta Caridad" EAD

    Plovdiv, 4004, Bulgaria

  • "Multiprofile Hospital for Active Treatment "Sveti Ivan Rilski - 2003" OOD

    Dupnitsa, 2600, Bulgaria

  • "Multiprofile Hospital for Active Treatment "Sveti Panteleymon"-Yambol AD

    Yambol, 8600, Bulgaria

  • "Multiprofile Hospital for Active Treatment - Blagoevgrad" AD

    Blagoevgrad, 2700, Bulgaria

  • "Multiprofile Hospital for Active Treatment - Haskovo" AD

    Haskovo, 6304, Bulgaria

  • "Multiprofile Hospital for Active Treatment - Uni Hospital" OOD

    Panagyurishte, 4500, Bulgaria

  • "Multiprofile Regional Hospital for Active Treatment "Dr. St. Cherkezov"" AD

    Veliko Tarnovo, 5002, Bulgaria

  • "Prof. Dr. Octavian Fodor"

    Cluj-Napoca, 400162, Romania

  • "Sf. Constantin" Hospital

    Brasov, 500388, Romania

  • "University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov" EAD

    Sofia, 1606, Bulgaria

  • Assuta Medical center

    Tel Aviv, Israel

  • Bajai Szent Rókus Kórház, Sebészeti Osztály

    Baja, Bács-Kiskun Megye, 6500, Hungary

  • Békés-Megyei Központi Kórház, I. Sebészeti Osztály

    Gyula, 5600, Hungary

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Coltea Clinical Hospital, Department of General Surgery

    Bucharest, 30171, Romania

  • Complex Oncology Center - Vratsa - EOOD

    Vratsa, 3000, Bulgaria

  • County Emergency Clinical Hospital Craiova, Department of General Surgery I

    Craiova, 200642, Romania

  • County Emergency Clinical Hospital Craiova, Department of General Surgery II

    Craiova, 200642, Romania

  • County Emergency Clinical Hospital Craiova, Department of General Surgery III

    Craiova, 200642, Romania

  • County Emergency Clinical Hospital Timisoara "Pius Brînzeu"

    Timișoara, 300723, Romania

  • Csongrad-Csanad Megyei Egeszsegugyi Ellato Kozpont Hodmezovasarhely - Mako, Sebeszeti Osztaly

    Hódmezővásárhely, 6800, Hungary

  • Department - Surgery, "Multiprofile Hospital for Active Treatment - Hristo Botev" AD

    Vratsa, 3001, Bulgaria

  • Emergency University Hospital Elias, Clinical Department of General Surgery

    Bucharest, 11461, Romania

  • FNsP J.A. Reimana Presov Oddelenie chirurgie

    Prešov, 081 81, Slovakia

  • Fakultna nemocnica s poliklinikou Zilina Oddelenie chirurgie

    Žilina, 01001, Slovakia

  • Fakultni Nemocnice Brno Chirurgicka klinika

    Brno, 62500, Czechia

  • Fakultni nemocnice Kralovske Vinohrady Chirurgicka klinika

    Prague, 100 34, Czechia

  • Fejér Megyei Szent György Egyetemi Oktató Kórház, Sebészeti Osztály

    Székesfehérvár, 8000, Hungary

  • Galilee Medical Center

    Nahariya, Nahariya-Cabri, 22100, Israel

  • General Hospital Zadar

    Zadar, 23000, Croatia

  • IMSP Clinical Republican Hospital "Timofei Mosneaga"

    Chisinau, 2025, Moldova

  • IMSP Institute of Emergency Medicine

    Chisinau, 2004, Moldova

  • IMSP Institute of Oncology

    Chisinau, 2025, Moldova

  • IMSP Municipal Clinical Hospital "Sfanta Treime"

    Chisinau, 2068, Moldova

  • KBC Rijeka

    Rijeka, 51000, Croatia

  • KBC Sestre milosrdnice Klinika za tumore

    Zagreb, 10000, Croatia

  • Kaplan Medical Center

    Rehovot, Pasternak, 76100, Israel

  • Krajska nemocnice Liberec, a. s.

    Liberec, 46001, Czechia

  • Medical Center Dr.Ianosi, Department of Surgery

    Craiova, 200061, Romania

  • Nemocnice Na Bulovce

    Prague, 18081, Czechia

  • Oddzial Chirurgii Ogolnej i Onkologicznej, Szpital Uniwersytecki im.Karola Marcinkowskiego

    Zielona Góra, 65-046, Poland

  • Oddzial Kliniczny Chirurgii Onkologicznej, Bydgoszczy

    Bydgoszcz, 85-796, Poland

  • Orosházi Kórház, Invazív Mátrix Sebészet

    Orosháza, 5900, Hungary

  • PMSI Municipal Clinical Hospital No. 1 "Gheorghe Paladi" Department of General Surgery

    Chisinau, MD-2001, Moldova

  • Paradigm Clinical Research Center

    Redding, California, 96001, United States

  • Pécsi Tudományegyetem, Klinikai Központ, Sebészeti Klinika

    Pécs, 7624, Hungary

  • Rabin Medical Center

    Petah Tikva, Israel

  • Semmelweis Egyetem Altalanos Orvostudomanyi Kar, Sebeszeti es Intervencios Gasztroenterologiai

    Budapest, 1082, Hungary

  • Shamir (Assaf-Harofeh) Medical Center

    Zrifin, Israel

  • Shoals Medical Trials

    Sheffield, Alabama, 35660, United States

  • Somogy Megyei Kaposi Mór Oktató Kórház, Sebészeti Osztály

    Kaposvár, 7400, Hungary

  • Sourasky Medical Center

    Tel Aviv, Israel

  • Spitalul Clinic Judetean de Urgentã Targu-Mures

    Craiova, 200642, Romania

  • Summit Medical Group

    Bend, Oregon, 97701, United States

  • Szpital Skawina Sp. z o.o., im. Stanley Dudricka

    Skawina, 32-050, Poland

  • Szpital Specjalistyczny im. Zeromskiego,Oddzial Chirurgii Ogolnej Onkologicznej i Maloinwazyjnej

    Krakow, 31-913, Poland

  • The Chaim Sheba Medical Center

    Ramat Gan, Derech Sheba 2, Israel

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • University First Multiprofile Hospital for Active Treatment - Sofia Sv. Yoan Krastitel EAD

    Sofia, 1154, Bulgaria

  • University Hospital Centre Zagreb (KBC Rebro)

    Zagreb, 10000, Croatia

  • Vseobecna Nemocnica s Poliklinikou Lucenec Chirurgicke Oddelenie

    Lučenec, 98401, Slovakia

Conditions

Explore the condition pages connected to this study.

ABDOMINAL SURGERY COLON SURGERY POST-OP INFECTION SURGICAL SITE INFECTION