New cell therapy aims to tame deadly transplant complication

NCT ID NCT05643638

Ongoing Disease control Sponsor: Cynata Therapeutics Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new treatment called CYP-001 for people who develop a severe immune reaction (graft versus host disease) after a stem cell transplant. About 60 participants will receive either CYP-001 plus standard steroids or a placebo plus steroids. The goal is to see if adding CYP-001 improves the chance of controlling the disease without needing more treatments.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute graft versus host disease graft versus host disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAFT VERSUS HOST DISEASE, ACUTE

Contacts and locations

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Locations

ASST Grande Ospedale Metropolitano Niguarda

Milan, Italy
Anadolu Medical Center

Eskişehir, Turkey (Türkiye)
Azienda Ospedaliero Universitaria delle Marche

Ancona, Italy
BMT Group of Georgia

Atlanta, Georgia, 30342, United States
Banner MD Anderson

Phoenix, Arizona, 85012, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Clínica Universidad de Navarra

Pamplona, Spain
Dr Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi

Yenimahalle, Turkey (Türkiye)
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, Italy
Gayrettepe Florence Nightingale Hastanesi

Istanbul, 34318, Turkey (Türkiye)
Hospital Claude Huriez

Lille, France
Hospital Universitario Fundacion Jimenez Diaz

Madrid, Spain
Hospital Universitario Ramon y Cajal

Madrid, Spain
Hospital Universitario Virgen de la Arrixaca

Murcia, Spain
Hospital Universitato De La Princesa

Madrid, Spain
Hôpital Necker Enfants Malades

Paris, France
Hôpital Universitaire Pitié-Salpêtrière

Paris, France
ICO l'Hospitalet - Hospital Duran i Reynals

Barcelona, Spain
IRCCS Ospedale Casa Sollievo della Sofferenza

San Giovanni Rotondo, Italy
Istituto Clinico Humanitas

Rozzano, Italy
Izmir Medicalpark Hospital

Izmir, Turkey (Türkiye)
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Koc University

Istanbul, Turkey (Türkiye)
Mayo Clinic Hospital

Phoenix, Arizona, 85288, United States
Mayo Clinic Hospital

Jacksonville, Florida, 32224, United States
Memorial Bahcelievler Hospital

Istanbul, Turkey (Türkiye)
Memorial healthcare System

Pembroke Pines, Florida, 33026, United States
Northwestern University

Evanston, Illinois, 60208, United States
Ospedale dell'Angelo di Mestre

Venezia, Italy
Penn State Health

Hershey, Pennsylvania, 17033, United States
Royal Brisbane and Women's Hospital

Herston, Queensland, 4029, Australia
Royal Prince Alfred Hospital

Sydney, New South Wales, 2050, Australia
University Of Nebrasaka Medical Center

Omaha, Nebraska, 68198, United States
University of Arkansas Medical Center

Little Rock, Arkansas, 72205, United States
University of Utah

Salt Lake City, Utah, 84112, United States
Vilnius University Hospital Santaros Klinikos

Vilnius, Lithuania
Weill Cornell Medicine - New York Presbyterian Hospital

New York, New York, 10065, United States
Westmead Hospital

Westmead, New South Wales, 2145, Australia
İnonu University

Malatya, Turkey (Türkiye)