New pill could ease schizophrenia psychosis

NCT ID NCT05227703

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 26 times

Summary

This study tested a new drug called CVL-231 (Emraclidine) in 391 adults with schizophrenia who were having a sudden worsening of psychotic symptoms. Participants took either a low dose, a high dose, or a placebo pill daily for 6 weeks. The goal was to see if the drug reduces symptoms like hallucinations and confusion better than a placebo.

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Contacts and locations

Locations

  • Atlanta, Georgia

    Atlanta, Georgia, 30331-2012, United States

  • Austin, Texas

    Austin, Texas, 78754-5122, United States

  • Bellflower, California

    Bellflower, California, 90706-7079, United States

  • Bentonville, Arkansas

    Bentonville, Arkansas, 72712-3873, United States

  • Berlin, New Jersey

    Berlin, New Jersey, 08009, United States

  • Budapest, Budapest

    Budapest, 1083, Hungary

  • Burgas, Burgas

    Burgas, 8000, Bulgaria

  • Charlotte, North Carolina

    Charlotte, North Carolina, 28211-4849, United States

  • Chicago, Illinois

    Chicago, Illinois, 60640-5017, United States

  • Chicago, Illinois

    Chicago, Illinois, 60641, United States

  • Győr, Győr-Moson-Sopron

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Homestead, Florida

    Homestead, Florida, 33032-8187, United States

  • Kalocsa, Bács-Kiskun

    Kalocsa, Bács-Kiskun county, 6300, Hungary

  • La Habra, California

    La Habra, California, 90631-3842, United States

  • Marlton, New Jersey

    Marlton, New Jersey, 08053, United States

  • Miami Lakes, Florida

    Miami Lakes, Florida, 33016-1553, United States

  • Miami Springs, Florida

    Miami Springs, Florida, 33166-7225, United States

  • Miami, Florida

    Miami, Florida, 33122-1335, United States

  • New Haven, Connecticut

    New Haven, Connecticut, 06519-1109, United States

  • Pleven, Pleven

    Pleven, 5800, Bulgaria

  • San Diego, California

    San Diego, California, 92103-2209, United States

  • Savannah, Georgia

    Savannah, Georgia, 31405-5701, United States

  • Sherman Oaks, California

    Sherman Oaks, California, 91403-1747, United States

  • Sofia, Sofia

    Sofia, 1282, Bulgaria

  • Sofia, Sofia-Grad

    Sofia, Sofia-Grad, 1431, Bulgaria

  • Torrance, California

    Torrance, California, 90504-4432, United States

Conditions

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