Cuff training may rev up muscle batteries without heavy lifting
NCT ID NCT07494721
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether low-load exercise with pressure cuffs on the legs can improve mitochondrial capacity—the energy powerhouses of muscle cells—in people with physical deconditioning. Fifty-one participants will do either strength or endurance training with cuffs, while a control group does standard rehab without cuffs. Muscle oxygen is measured non-invasively using light sensors.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- pressure cuffs applied during strength or endurance training
- What this could lead to
- If successful, this could point toward a simple, low-load exercise method to improve muscle energy use in people who are physically deconditioned.
- What could go wrong
- This is a small, early-stage study (51 participants) that measures short-term changes only. The results may not apply to broader populations or lead to a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 51 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion: * Medically confirmed generalized deconditioning with reduced muscle strength * Medical certification of suitability for functional lower-extremity strength training * Written informed consent after an adequate reflection period Exclusion: * Unstable arrhythmias, myocardial ischemia, symptomatic blood pressure drops or hypertension (\>160/100 mmHg despite medication) * History of thrombosis or acute swelling/skin discoloration of the legs * Dizziness, confusion, cyanosis, or unexplained fatigue * Participant's wish to withdraw or not participate
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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