New drug combo shows promise against HPV head and neck cancer

NCT ID NCT03978689

First seen Jan 24, 2026 · Last updated May 16, 2026 · Updated 15 times

Summary

This early-stage study tested a new drug called CUE-101, alone or with another drug (pembrolizumab), in 80 people with a type of head and neck cancer linked to HPV. The main goals were to check safety and find the right dose. Researchers also looked at whether the tumors shrank. This is not a cure, but aims to control the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Affiliated Oncologists, LLC

    Chicago, Illinois, 33612, United States

  • Barbara Karmanos Cancer Center/ Wayne State University School of Medicine

    Detroit, Michigan, 48201, United States

  • Emory University School of Medicine

    Atlanta, Georgia, 30322, United States

  • Gabrail Cancer Center

    Canton, Ohio, 44718, United States

  • George Washington University Cancer Center

    Washington D.C., District of Columbia, 20037, United States

  • Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

    Baltimore, Maryland, 20231, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10017, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Stanford University Medical Center

    Palo Alto, California, 94305, United States

  • University of Arizona

    Tucson, Arizona, 85719, United States

  • University of Michigan

    Ann Arbor, Michigan, 48197, United States

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • University of Washington School of Medicine

    Seattle, Washington, 98195, United States

  • Vanderbilt-Ingram Cancer Center (VICC)

    Nashville, Tennessee, 37232, United States

  • Washington University

    St Louis, Missouri, 63110, United States

  • Yale School of Medicine

    New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.