Gene therapy injection aims to halt vision loss in AMD patients

NCT ID NCT07392255

Recruiting now Disease control Sponsor: Complement Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a single injection of CTx001 gene therapy into the eye for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. The trial involves 75 participants and will monitor safety and whether the treatment can slow damage to the retina over two years, with long-term follow-up up to five years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CTx001 (gene therapy)
What this could lead to: If successful, this could slow or stop the progression of geographic atrophy, preserving vision in people with age-related macular degeneration.
What could go wrong: This is an early Phase 1/2 trial with only 75 participants, so results may not apply to everyone. Gene therapy via subretinal injection carries risks like inflammation or vision loss.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Gundersen Health System
RECRUITING

La Crosse, Wisconsin, 54601, United States
Midwest Eye Institute
RECRUITING

Carmel, Indiana, 46290, United States
Retina Foundation of the Southwest
RECRUITING

Dallas, Texas, 75231, United States
Sierra Eye Associates
RECRUITING

Reno, Nevada, 89502, United States
The Retina Clinic London
RECRUITING

London, London, W1G 7LB, United Kingdom

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