Smart scans and DNA tests guide lymphoma therapy, reducing unnecessary drugs
NCT ID NCT04604067
First seen Jan 06, 2026 · Last updated May 14, 2026 · Updated 23 times
Summary
This study tests whether using ctDNA blood tests and PET scans can help doctors tailor treatment for people with diffuse large B-cell lymphoma (DLBCL). About 260 participants will receive standard chemotherapy (R-CHOP) plus or minus a targeted drug (acalabrutinib) based on their genetic mutations and early response to treatment. The goal is to see if this personalized approach can improve outcomes and reduce side effects by avoiding unnecessary or ineffective treatments.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Azienda Ospedaliera Universitaria Maggiore della Carita di Novara
Novara, 20503, Italy
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Centre Hospitalier Universitaire Vaudois
Lausanne, CH-1011, Switzerland
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City Hospital Triemli
Zurich, CH-8063, Switzerland
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Hopital Fribourgeois
Fribourg, 1708, Switzerland
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Hopitaux Universitaire de Genève (HUG)
Geneva, 1211, Switzerland
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Inselspital, Bern
Bern, CH-3010, Switzerland
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Istituto Oncologico della Svizzera Italiana
Bellinzona, 6500, Switzerland
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Kantonsspital Aarau
Aarau, CH-5001, Switzerland
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Kantonsspital Baden (Baden/Brugg)
Baden, 5404, Switzerland
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Kantonsspital Graubünden
Chur, 7000, Switzerland
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Kantonsspital Luzern
Luzerne, CH-6000, Switzerland
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Kantonsspital Olten
Olten, CH-4600, Switzerland
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Kantonsspital St. Gallen
Sankt Gallen, 9007, Switzerland
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Kantonsspital Winterthur
Winterthur, 8401, Switzerland
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Ospedale Papa Giovanni XXIII
Bergamo, 24127, Italy
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Policlinico Agostino Gemelli
Roma, 00168, Italy
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Réseau Hospitalier Neuchâtelois (RHNe)
Neuchâtel, 2000, Switzerland
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St. Claraspital
Basel, 4058, Switzerland
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UniversitätsSpital Zürich
Zurich, 8091, Switzerland
Conditions
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