Blood test may predict cancer recurrence in head and neck patients

NCT ID NCT06479070

Recruiting now Knowledge-focused Sponsor: Institut de Cancérologie de Lorraine Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether measuring circulating tumor DNA (ctDNA) in the blood can predict if cancer will come back after radiation therapy. Researchers will collect blood samples from 188 patients with advanced head and neck cancer before, during, and after treatment. The goal is to see if a drop in ctDNA levels one month after treatment can forecast progression-free survival at two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple blood test to predict cancer recurrence earlier, helping doctors tailor follow-up care.
What could go wrong: This is an observational study, not a treatment trial. It may not show a clear link between ctDNA levels and outcomes, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Head and Neck Neoplasms head and neck squamous cell carcinoma neoplasm squamous cell carcinoma upper aerodigestive tract neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCC - SQUAMOUS CELL CARCINOMA UPPER AERO-DIGESTIVE TRACT (UADT) NEOPLASM

Contacts and locations

Locations

CHU Besançon
RECRUITING

Besançon, 25030, France
Centre François Baclesse
RECRUITING

Caen, Caen, 14076, France
Centre Georges-François Leclerc
RECRUITING

Dijon, 21000, France
Institut de Cancérologie Strasbourg Europe
RECRUITING

Strasbourg, 67033, France
Institut de Cancérologie de Lorraine
RECRUITING

Vandœuvre-lès-Nancy, Grand Est, 54500, France
Intitut Jean Godinot
RECRUITING

Reims, 51100, France
University Hospital Zurich (USZ)
RECRUITING

Zurich, Canton of Zurich, 8091, Switzerland

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