Freeze and pill combo takes on rare tumors
NCT ID NCT05949099
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests a two-step approach for desmoid tumors, which are non-cancerous but can be painful and grow. First, patients take a daily pill called nirogacestat for three months. Then, one tumor is frozen with a special needle (cryoablation). The goal is to see if this combination can stop the tumor from growing or shrink it for at least a year. The trial is recruiting 28 adults with progressing or symptomatic tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nirogacestat (a drug taken by mouth) and cryoablation (a procedure that freezes the tumor)
What this could lead to
If it works, this could offer a new way to control desmoid tumors without major surgery, potentially shrinking or stabilizing the tumor for a year or more.
What could go wrong
This is a small, early-phase trial with only 28 participants, so results may not apply to everyone. The drug and procedure have side effects, and the tumor may still grow or come back.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Stanford University
RECRUITINGPalo Alto, California, 94395, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••