Freeze and pill combo takes on rare tumors

NCT ID NCT05949099

Recruiting now Disease control Sponsor: Nam Bui Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests a two-step approach for desmoid tumors, which are non-cancerous but can be painful and grow. First, patients take a daily pill called nirogacestat for three months. Then, one tumor is frozen with a special needle (cryoablation). The goal is to see if this combination can stop the tumor from growing or shrink it for at least a year. The trial is recruiting 28 adults with progressing or symptomatic tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nirogacestat (a drug taken by mouth) and cryoablation (a procedure that freezes the tumor)
What this could lead to: If it works, this could offer a new way to control desmoid tumors without major surgery, potentially shrinking or stabilizing the tumor for a year or more.
What could go wrong: This is a small, early-phase trial with only 28 participants, so results may not apply to everyone. The drug and procedure have side effects, and the tumor may still grow or come back.

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Conditions

The condition(s) this trial relates to.

desmoid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DESMOID TUMOR

Contacts and locations

Locations

Stanford University
RECRUITING

Palo Alto, California, 94395, United States

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