New PNH drug crovalimab faces off against eculizumab in phase 3 trial
NCT ID NCT04432584
First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 3 times
Summary
This phase 3 trial compares crovalimab, a new injectable drug, to eculizumab in about 190 people with paroxysmal nocturnal hemoglobinuria (PNH) who are already on complement inhibitors. The study aims to see if crovalimab is as safe and effective, with a focus on side effects and how the body processes the drug. Participants will receive either crovalimab or continue eculizumab, and the results could lead to a more convenient treatment option.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Crovalimab (a drug given by injection under the skin or into a vein)
- What this could lead to
- If it works, crovalimab could offer a more convenient treatment option for people with PNH, potentially requiring fewer injections than current therapies.
- What could go wrong
- This is a phase 3 trial, but it's comparing two similar drugs, so the benefit over eculizumab may be small. Risks include injection-site reactions, infections, and possible drug interactions when switching treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PAROXYSMAL NOCTURNAL HEMOGLOBINURIA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
*X*CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia
Santo André, São Paulo, 09060-870, Brazil
-
AZ Delta Campus Westlaan
Roeselare, 8800, Belgium
-
Akademiska Sjukhuset
Uppsala, 751 85, Sweden
-
Amsterdam UMC, Locatie AMC
Amsterdam, 1105 AZ, Netherlands
-
Attikon University General Hospital
Athens, 124 62, Greece
-
Azienda Ospedaliera Città della Salute e della Scienza di Torino
Turin, Piedmont, 10126, Italy
-
Azienda Ospedaliera Universitaria Careggi
Florence, Tuscany, 50134, Italy
-
Azienda Unita Sanitaria Locale- Ravenna
Ravenna, Emilia-Romagna, 48121, Italy
-
Beneficencia Portuguesa de Sao Paulo
São Paulo, 01321-00, Brazil
-
Carolinas Healthcare System
Charlotte, North Carolina, 28204, United States
-
Centro Hospitalar do Baixo Vouga E.P.E. - Hospital de Aveiro
Aveiro, 3814-501, Portugal
-
Centro Hospitalar do Porto - Hospital de Santo António
Porto, 4099-001, Portugal
-
Changhua Christian Hospital
Chang-hua, 500, Taiwan
-
Chronos Pesquisa Clinica
Taguatinga, Federal District, 72145-450, Brazil
-
Cliniques Universitaires Saint-Luc
Brussels, 1200, Belgium
-
Complejo Hospitalario Universitario de Santiago.
Santiago de Compostela, LA Coruna, 15706, Spain
-
ELBLANDKLINIKUM Riesa
Riesa, 01589, Germany
-
Ege University Medical Faculty; Hematology
Izmir, 35040, Turkey (Türkiye)
-
Fondazione IRCCS CA? Granda Ospedale Maggiore Policlinico
Milan, Lombardy, 20122, Italy
-
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Lazio, 00168, Italy
-
Fujita Health University Hospital
Aichi, 470-1192, Japan
-
Gaziantep University Medical Faculty Sahinbey Educational Research Hospital; Hematology
Gaziantep, 27310, Turkey (Türkiye)
-
General Hospital of Athens LAIKO
Athens, 115 27, Greece
-
Hacettepe University Medical Faculty; Neurology
Ankara, 06100, Turkey (Türkiye)
-
Hopital Claude Huriez - CHU Lille
Lille, 59037, France
-
Hospital General Universitario Gregorio Marañon
Madrid, 28009, Spain
-
Hospital Paulistano
São Paulo, São Paulo, 01321-000, Brazil
-
Hospital Regional Universitario de Malaga
Málaga, 29010, Spain
-
Hospital Sírio-Libanês
São Paulo, São Paulo, 01308-050, Brazil
-
Hospital U. Central de Asturias
Asturias, Principality of Asturias, 33011, Spain
-
Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
-
Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
-
Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
-
Hospital Universitario de Salamanca
Salamanca, 37007, Spain
-
Hospital Universitario de Toledo
Toledo, 45007, Spain
-
Hospital das Clínicas FMRP-USP
Ribeirão Preto, São Paulo, 14048-900, Brazil
-
Hospital de Basurto
Bilbao, Vizcaya, 48013, Spain
-
Hospital de Clínicas de Porto Alegre X
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
-
Hualien Tzu Chi Hospital
Hualien City, DUMMY_VALUE, Taiwan
-
ICO Badalona - Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, 08916, Spain
-
Institut Paoli Calmette
Marseille, 13273, France
-
Instituto Joinvilense de Hematologia E Oncologia
Joinville, Santa Catarina, 89201-260, Brazil
-
Ishikawa Prefectural Central Hospital
Ishikawa, 920-8530, Japan
-
Istanbul University Istanbul Medical Faculty; Neurology
Istanbul, 34093, Turkey (Türkiye)
-
Iwate Prefectural Isawa Hospital
Ōshū, 023-0864, Japan
-
Japanese Red Cross Society Suwa Hospital
Nagano, 392-8510, Japan
-
King Faisal Specialist Hospital & Research Center
Riyadh, 11211, Saudi Arabia
-
King'S College Hospital
London, SE5 9RS, United Kingdom
-
Kobe University Hospital
Hyōgo, 650-0017, Japan
-
MTZ Clinical Research Powered by Pratia
Warsaw, 02-172, Poland
-
Marmara University Pendik Training and Research Hospital, Hematology Department
Istanbul, 34300, Turkey (Türkiye)
-
Mie University Hospital
Mie, 514-8507, Japan
-
NTT Medical Center Tokyo
Tokyo, 141-8625, Japan
-
Nagasaki University Hospital
Nagasaki, 852-8501, Japan
-
National Hospital Organization Okayama Medical Center
Okayama, 701-1192, Japan
-
National Taiwan Universtiy Hospital
Taipei, 100, Taiwan
-
National University Hospital
Singapore, 117599, Singapore
-
Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
-
North Estonia Medical Centre Foundation
Tallinn, 13419, Estonia
-
Ondokuz Mayis Univ. Med. Fac.
Samsun, 55139, Turkey (Türkiye)
-
Pratia Poznan
Skórzewo, 60-185, Poland
-
Prince of Wales Hospital
Hong Kong, 999077, Hong Kong
-
Samodzielny Publiczny Szpital Kliniczny nr 1
Lublin, 20-081, Poland
-
Samsung Medical Center
Seoul, 06351, South Korea
-
Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
-
Sasebo City General Hospital
Nagasaki, 857-8511, Japan
-
Semmelweis Egyetem
Budapest, 1088, Hungary
-
Seoul National University Hospital
Seoul, 03080, South Korea
-
Severance Hospital
Seoul, 03722, South Korea
-
St James's Hospital
Dublin, D08NYH1, Ireland
-
Szpital Uniwersytecki nr2 im. dr J. Biziela
Bydgoszcz, 85-168, Poland
-
The University of Osaka Hospital
Osaka, 565-0871, Japan
-
Tokai University Hospital
Kanagawa, 259-1193, Japan
-
Tokushukai Takasago Seibu Hospital
Hyōgo, 676-0812, Japan
-
Tokyo Medical University Hospital
Tokyo, 160-0023, Japan
-
Toyama Prefectual Central Hospital
Toyama, 930-8550, Japan
-
Ulsan University Hospital
Ulsan, 44033, South Korea
-
Universitaetsklinikum Aachen AOeR
Aachen, 52074, Germany
-
Uniwersyteckie Centrum Kliniczne
Gda?sk, 80-214, Poland
-
Ustav hematologie a krevni transfuze
Prague, 128 00, Czechia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A pill that could replace infusions for a rare blood disease?
- Every-8-Week shot could simplify PNH treatment
- Real-World test: can a targeted drug keep PNH in check for years?
- New transplant method aims to reduce complications in bone marrow failure patients
- No treatment, just observation: large study looks at PNH blood cells
- New hope for rare blood disorder: Long-Term study of XH-S003 underway